Lielpetere, A; Jirgensons, A. Carbenium ion formation by fragmentation of electrochemically generated oxonium ions. Org. Biomol. Chem. 2018, 16 (28), 5094-5096. doi:10.1039/c8ob01339j.

Charlton, M.H.; Aleksis, R.; Saint-Leger, A.; Gupta, A; Loza, E.; , Ribas De Pouplana, L.;  Kaula, I.;  Gustina, D.; Madre, M.; Lola, D;  Jaudzems, K.;  Edmund, G.; Randall, C.P.; Kime, L.;  O’Neill, A.J.;, Goessens, W.; Jirgensons, A.; Finn, P.W.  N-Leucinyl Benzenesulfonamides as Structurally Simplified Leucyl-tRNA Synthetase Inhibitors. ACS Med. Chem. Lett.  2018, 9 (2), 84-88. doi: 1021/acsmedchemlett.7b00374.

Rasina, D.; Stakanovs, G.; Borysov, O.V.; Pantelejevs, T.; Bobrovs, R.; Kanepe-Lapsa, I.; Tars, K.; Jaudzems, K.; Jirgensons, A. 2-Aminoquinazolin-4(3H)-one based plasmepsin inhibitors with improved hydrophilicity and selectivity. Biorg & Med. Chem. 2018, 26 (9), 2488-2500. doi: 1016/j.bmc.2018.04.012.

Kinena, L.; Leitis, G.; Kanepe-Lapsa, I.; Bobrovs, R.; Jaudzems, K.; Ozola, V.; Suna, E., Jirgensons, A. Azole-based non-peptidomimetic plasmepsin inhibitors. Arch. Pharm. 2018, 351(9), 1800151. doi: 10.1002/ardp.201800151

Skvorcova, M; Jirgensons, A. Amide-Group-Directed Protonolysis of Cyclopropane: An Approach to 2,2-Disubstituted Pyrrolidines. Org.Lett. 2017, 19 (10), 2478–2481.

Skvorcova, M; Jirgensons, A. Intramolecular cyclopropylmethylation via non-classical carbocations. Org. Biomol. Chem., 2017, 15, 6909-6912.

Grammatoglou, K; Bolsakova, J; Jirgensons, A. C-Quaternary alkynyl glycinols via the Ritter reaction of cobalt complexed alkynyl glycols RSC Adv. 2017, 7, 27530-27537.

Bolsakova, J.; Jirgensons, A. The Ritter reaction for the synthesis of heterocycles. Chem. Heterocycl. Compd. 2017, 53(11), 1167-1177. doi: 10.1007/s10593-018-2189-y.

Skvorcova, M., Grigorjeva, L., Jirgensons, A. 1-Amino-1-hydroxymethylcyclobutane derivatives via intramolecular amination of nonclassical cyclopropylmethyl cation. Chem. Heterocycl. Compd. 2017, 53(9), 989-996.   doi: 10.1007/s10593-017-2162-1.

Petrova, E; Rasiņa, D;  Jirgensons, A. N-Sulfonylcarboxamide as an Oxidizing Directing Group for Ruthenium-Catalyzed C–H Activation/Annulation. J. Org. Chem. 2017, DOI: 10.1002/ejoc.201601582.

Skvorcova, M; Jirgensons, A. Allylic Amination via Acid Catalyzed Leaving Group Activation. Current Green Chemistry 2016, 3(2), 145 – 159.

Bolsakova, J.; Jirgensons, A. Synthesis of alfa-Ethynyl Glycines. Eur. J. Org. Chem. 2016, (27), 4591–4602.

Monteferrante, C.; Jirgensons ; Varik, V.; Hauryliuk, V.; Goessens, W.; Hays, J.  Evaluation of the characteristics of  leucyl-tRNA synthetase (LeuRS) inhibitor AN3365 in combination with different antibiotic classes International Journal of Antimicrobial Agents Eur. J. Clin. Microbiol. Infect. Dis. 2016. doi:10.1007/s10096-016-2738-1.

Randall, C.; Rasina, D.; Jirgensons, A.; O’Neill, A. Targeting multiple aminoacyl tRNA synthetases overcomes the resistance liabilities associated with antibacterial inhibitors acting on a single such enzyme Antimicrobial Agents and Chemotherapy 2016, doi: 10.1128/AAC.00674-16.

Recacha, R.; Jaudzems, K.; Akopjana, I.; Jirgensons, ; Tars, K. Crystal structure of Plasmodium falciparum proplasmepsin IV: the plasticity of proplasmepsins Acta Crystallographica Section F 2016, 72 (9), 659–666.

Gupta, A.; · Monteferrante, C.; ·Rasina, D. ·Leitis, G.; Randall,· C. P.; Tomlinson, J. H. Jirgensons, A.;· Goessens, W.H.F.; Hays, J. P.;· O’Neill, A. J. Drug resistance without drug selection: polymorphism in leuS confers reduced susceptibility to GSK2251052 in a clinical isolate of Staphylococcus aureus. Antimicrobial Agents and Chemotherapy 2016, 60(5), published online, DOI: 10.1128/AAC.02940-15.

Rasina, D.;  Otikovs, M.; Leitans, J; . Recacha, R.; Borysov, O. V.;  Kanepe-Lapsa, I.; Domraceva, I.; Pantelejevs, T.;  Tars, K.;  Blackman, M. J.; Jaudzems, K.;  Jirgensons,  A. Fragment-Based Discovery of 2-Aminoquinazolin-4(3H)-ones As Novel Class Nonpeptidomimetic Inhibitors of the Plasmepsins I, II, and IV. J. Med. Chem. 2016, 59, 374–387, DOI; 10.1021/acs.jmedchem.5b01558.

Sirotkina, J.; Grigorjeva, L.; Jirgenons, A. Synthesis of Alkynyl Glycinols via Lewis Acid Catalyzed Propargylic Substitution of bis-Imidates. Eur. J. Org. Chem. 2015. Accepted for publication, DOI: 10.1002/ejoc.201500937

Nikitjuka, A.; Shestakova, I.; Romanchikova, N.; Jirgensons A. Synthesis and biological evaluation of aziridin-1-yl oxime-based vorinostat analogs as anticancer agents. Chem. Heterocycl. Compd., 2015, 51(7), 647-657, DOI: 10.1007/s10593-015-1752-z.

Skvorcova, M.; Grigorjeva, L; Jirgensons, A. Tetrahydro-1,3-oxazepines via Intramolecular Amination of Cyclopropylmethyl Cation. Org.Lett., 2015, 17, 2902–2904, DOI: 10.1021/acs.orglett.5b01014.

Kumar, V.; Klimovica, K.;  Rasina, D. Jirgensons A. 2-Vinyl Threoninol Derivatives via Acid-Catalyzed Allylic Substitution of Bisimidates. J. Org. Chem., 2015, 80, 5934–5943, DOI: 10.1021/acs.joc.5b00529.

Grigorjeva,  L;  Kinens, A.;  Jirgensons,  A. Unsaturated syn– and anti-1,2-Amino Alcohols by Cyclization of Allylic Bis-trichloroacetimidates. Stereoselectivity Dependence on Substrate Configuration. J. Org. Chem., 2015, 80, 920–927, DOI: 10.1021/jo502404y.

Nikitjuka, A.;  Nekrasova, A.; Jirgensons A. Methylprenyl and Prenyl Protection for Sulfonamides. Synlett, 2015,  26, 183-186, DOI: 10.1055/s-0034-1379428.

Recacha R.; Leitans J.; Akopjana I.; Aprupe L.; Trapencieris P.; Jaudzems K.; Jirgensons A.; Tars K. Structures of plasmepsin II from Plasmodium falciparum in complex with two hydroxyethylamine-based inhibitors. Acta Cryst. 2015. F71, 1531-1539 DOI: http://10.1107/S2053230X15022049`

Kher, S. S.; Jirgensons, A. Synthesis of β-amino-α -ketoamides (Review). Curr. Org. Chem., 2014, 18, 2240-2269, DOI: 10.2174/1385272819666140818223225.

Kher, S. S.; Penzo, M.; Fulle, S.; Ebejer,  J. P.;  Finn, P. W. ; Blackman, M. J.; Jirgensons, A.  Quinoxaline based inhibitors of malarial protease PfSUB. Chem. Heterocycl. Compd.(russ), 2014, 10, 1583—1589, DOI 10.1007/s10593-014-1610-4.

Kher, S. S.; Penzo, M.; Fulle, S.; Finn, P. W. ; Blackman, M. J.; Jirgensons, A. Substrate derived peptidic α-ketoamides as inhibitors of the malarial protease PfSUB1.Bioorg. Med. Chem. Lett.,  2014, 24(18), 4486-4489, DOI: 10.1016/j.bmcl.2014.07.086.

Grigorjeva, L.; Liepinsh, E.; Razafimahefa, S.; Yahorau, A.; Yahorava, S.; Rasoanaivo, P.; Jirgensons, A.; Wikberg,   J. E. S. Semisynthesis of libiguin A and its analogues by trans-lactonization of phragmalin. J. Org. Chem., 2014, 79(9), 4148–4153, DOI: 10.1021/jo500318w.

Jaudzems, K.; Tars, K.; Maurops, G.; Ivdra, N; Otikovs, M. ; Leitans, J.; Kanepe-Lapsa, I.; Domraceva, I.; Mutule, I.; Trapencieris, P.; Blackman, M. J.; Jirgensons, A. Plasmepsin Inhibitory Activity and Structure-Guided Optimization of a Potent Hydroxyethylamine-Based Antimalarial. Hit. ACS Med. Chem. Lett., 2014, 5(4), 373–377, DOI: 10.1021/ml4004952.

Nikitjuka, A.; Jirgensons, A. Synthesis, Chemical and Biological Properties of Aziridine-1-carbaldehyde oximes (review). Chemistry of Heterocyclic Compounds (russ) 2013, 11, 1669-1684, DOI: 10.1007/s10593-014-1407-5. Dedicated to Professor Jānis Stradiņš on the occasion of his 80 anniversary.

Jirgensons, A.; Grigorjeva, L.; Maleckis, A.; Klimovica, K. Unsaturated Amino Alcohols via Cyclization of Allylic Bistrichloroacetimidates. Synlett, 2013, 24(18), 2345-2349, DOI: 10.1055/s-0033-1338977.

Katkevica, S.; Salun, P.; Jirgensons, A. Synthesis of 5-Substituted 3-Mercapto-1,2,4-Triazoles via Suzuki–Miyaura reaction. Tetrahedron Lett., 2013, 54, 4524–4525, DOI: 10.1016/j.tetlet.2013.06.067.

Nikitjuka, A; Jirgensons, A. Synthesis of Hydroxamic Acids by Using the Acid Labile O-2-Methylprenyl Protecting Group. Synlett 2012, 23, 2972-2974, DOI: 10.1055/s-0032-1317687.

Grigorjeva, L.; Jirgensons, A. Synthesis of Cyclic N-Tosyl-iminocarbonates by Lewis Acid Catalysed Allylic Substitution of Trichloroacetimidates. Eur. J. Org. Chem., 2012, 27, 5307–5316, DOI: 10.1002/ejoc.201200378.

Grigorjeva, L; Maleckis, A; Klimovica, K.; Skvorcova, M; Ivdra, N.; Leitis, G.; Jirgensons, A. Novel synthesis of 2-trichloromethyl-4-vinyl-oxazoline and its derivatization by ring cleavage reactions. Chem. Heterocycl. Compd. (russ), 2012, N6 (540), 989-994. Dedicated to professor Ivars Kalvinsh on the occasion of his 65th birthday.

Withers-Martinez, C.; Suarez, C.; Fulle, S.; Kher, S.; Penzo, M.; Ebejer, J.-P.; Koussis, K.; Hackett, F.; Jirgensons, A.; Finn, P.; Blackman, M. J. Plasmodium subtilisin-like protease 1 (SUB1): Insights into the active-site structure, specificity and function of a pan-malaria drug target. International Journal for Parasitology 2012, 42, 597-612, DOI: 10.1016/j.ijpara.2012.04.005.

Klimovica, K.; Grigorjeva, L. Maleckis, A.; Popelis, J.; Jirgensons, A. C-Quaternary vinylglycinols by metal catalysed cyclization of allylic bis-trichloroacetimidates. Synlett, 2011, 2849-2851, DOI: 10.1055/s-0031-1289537.

Grigorjeva, L.; Jirgensons, A. Lewis Acid Catalyzed Intramolecular Allylic Substitution of Bis(trichloroacetimidates): A Versatile Approach to Racemic Unsaturated Amino Acids. Eur. J. Org. Chem., 2011, 2421–2425, DOI: 10.1002/ejoc.201100060.

Maleckis, A.; Klimovica, K.; Jirgensons, A. Catalytic Enantioselective Synthesis of 4-Vinyl-2-Trichloromethyloxazoline: an Access to Enantioenriched Vinylglycinol surrogate. J. Org. Chem., 2010, 75, 7897-7900, DOI: 10.1021/jo101781y.

Usachova, N.; Leitis, G.; Jirgensons, A.; Kalvinsh I. Synthesis of hydroxamic acids by activation of carboxylic acids with N,N’-carbonyldiimidazole: exploring the efficiency of the method. Synthetic Comm. 2010, 40, 927–935, DOI: 10.1080/00397910903026723.


Wikberg, J.; Jirgensons A., Liepinsh E. Novel Compounds, Their Manufacture and Uses (II). Patent No WO2013110744, A2, 01.08. 2013.

Gold M. R.; Kauss V.; Jirgensons A; Method For Preparing Neramexane or a Salt Thereof. Patent No WO2011035924, A1, 31. 03. 2011.

Gold, M. R.; Jirgensons, A; Huber, F. A. M. Method For Producing Memantine. WO 2010/069555 A1, 24. 06. 2010.

Maleckis, A.; Jirgensons, A. Enantioselektīva 2-trihlormetil-4-viniloksazolīna iegūšana, P-09-77. 2009

Finn, P; Robinson, D.; Kham, N.; Jirgensons, A.; Leitis, G.; Kalvinsh I. Bicyclosulfonyl acid (BCSA) Compounds and Their Use as Therapheutic Agents PCT /GB2008/001683, 16.05.2008

Comments are closed.