January 10, 2019

Dr. Dace Rasina

Principal Researcher, Project Leader

E-mail: dacerasina@osi.lv

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Curriculum Vitae

Carrier Latvian Institute of Organic Synthesis, Riga, Latvia
Since 2019 Principal Researcher
2017 Researcher
2011 Research Assistant
2009 Laboratory Assistant
Education 2017 Dr. Chem., Faculty of Materials Science and Applied Chemistry, Riga Technical University
2015 (Sept)–2016 (May) InnovaBalt Exchange Program, University of Perugia, Italy (Prof. L. Vaccaro Group)
2011 M.Sc. Chem., Faculty of Chemistry, University of Latvia
2009 B.Sc. Chem., Faculty of Chemistry, University of Latvia
2008 (Oct)–2009 (Feb) Erasmus Exchange Program, Leibniz University Hanover, Germany
Awards 2016  Scientific Achievement of the Year by Latvian Academy of Science
2012  Latvian Academy of Science, E. Gudriniece Award for the Master Thesis
2011   LLC “Bapeks” Poster Award in 7th Paul Walden Symposium on Organic Chemistry
2005–2007 Zvejnieku Family Scholarship from Foundation “Vitols Fund”

List of Publications

10. A Novel Collaborative Approach to Facilitate Chemical Biology

Brennecke, P.; Rasina, D.; Aubi, O.; Herzog, K.; Landskron, J.; Cautain, B.; Vicente, F.; Quintana, J.; Mestres, J.; Stechmann, B.; Ellinger, B.; Brea, J; Kolanowski, J. L.; Pilarski, R.; Orzaez, M.; Pineda-Lucena, A.; Laraia, L.; Nami, F.; Zielenkiewicz, P.; Paruch, K.; Hansen, E.; Von Kries, J. P.; Neuenschwander, M.; Specker, E.; Bartunek, P.; Simova, S.; Leśnikowski, Z.; Krauss, S.; Lehtiö, L.; Bilitewski, U.; Brönstrup, M.; Taskén, K.; Jirgensons, A.; Lickert, H.; Clausen, M. H.; Andersen, J. H.; Vicent, M. J.; Genilloud, O.; Martinez, A.; Nazaré, M.; Fecke, W.; Gribbon, P.
SLAS Discov., 2019, 24, 398–413. DOI:10.1177/2472555218816276



9. 2-Aminoquinazolin-4(3H)-one Based Plasmepsin Inhibitors with Improved Hydrophilicity and Selectivity

Rasina, D.; Stakanovs, G.; Borysov, O.V.; Pantelejevs, T.; Bobrovs, R.; Kanepe-Lapsa, I.; Tars, K.; Jaudzems, K.; Jirgensons, A. Biorg. Med. Chem., 2018, 26(9), 2488-2500. DOI:10.1016/j.bmc.2018.04.012



8. N-Sulfonylcarboxamide as an Oxidizing Directing Group for Ruthenium-Catalyzed C–H Activation/Annulation

Petrova, E.; Rasina, D.;  Jirgensons, A. Eur. J. Org. Chem., 2017, 1773-1779. DOI:10.1002/ejoc.201601582



7. Targeting Multiple Aminoacyl-tRNA Synthetases Overcomes the Resistance Liabilities Associated with Antibacterial Inhibitors Acting on a Single Such Enzyme

Randall, C.; Rasina, D.; Jirgensons, A.; O’Neill, A. Antimicrob. Agents Chemother., 2016, 60(10) 6359-6361. DOI:10.1128/AAC.00674-16



6. A Polymorphism in LeuS Confers Reduced Susceptibility to GSK2251052 in a Clinical Isolate of Staphylococcus Aureus

Gupta, A.; Monteferrante, C.; Rasina, D.; Leitis, G.; Randall, C.P.; Tomlinson, J.H. Jirgensons, A.; Goessens, W.H.F.; Hays, J.P.; O’Neill, A.J. Antimicrob. Agents Chemother., 2016, 60(5), 3219-3221. DOI:10.1128/AAC.02940-15



5. Fragment-Based Discovery of 2-Aminoquinazolin-4(3H)-ones as Novel Class Nonpeptidomimetic Inhibitors of the Plasmepsins I, II, and IV

Rasina, D.;  Otikovs, M.; Leitans, J.; Recacha, R.; Borysov, O.V.;  Kanepe-Lapsa, I.; Domraceva, I.; Pantelejevs, T.;  Tars, K.;  Blackman, M.J.; Jaudzems, K.;  Jirgensons,  A. J. Med. Chem., 2016, 59, 374–387. DOI:10.1021/acs.jmedchem.5b01558




4. Searching for Novel Reusable Biomass-Derived Solvents: Furfuryl Alcohol/Water Azeotrope as a Medium for Waste-Minimised Copper-Catalysed Azide–Alkyne Cycloaddition

Rasina D.; Francesco F.; Santoro S.; Lombi A.; Vaccaro L. Green Chem., 2016, 18, 6380-6386. DOI:10.1039/C6GC01941B



3. Heterogeneous Palladium-Catalysed Catellani Reaction in Biomass-Derived γ-Valerolactone

Rasina D.; Kahler-Quesada A.; Ziarelli S.; Warratz S.; Cao H.; Santoro S.; Ackermann L.; Vaccaro L. Green Chem., 2016, 18, 5025-5030. DOI:10.1039/C6GC01393G



2. C-H Arylations of 1,2,3-Triazoles by Reusable Heterogeneous Palladium Catalysts in Biomass-Derived γ-Valerolactone

Tian X.; Yang F., Rasina D.; Bauer M.; Warratz S.; Ferlin F.; Vaccaro L.; Ackermann L. Chem. Commun. 2016, 52, 9777-9780. DOI:10.1039/C6CC03468C



1. 2-Vinyl Threoninol Derivatives via Acid-Catalyzed Allylic Substitution of Bisimidates

Kumar, V.; Klimovica, K.;  Rasina, D.; Jirgensons A. J. Org. Chem., 2015, 80, 5934–5943. DOI:10.1021/acs.joc.5b00529