July 10, 2019

Dr. Anna Nikitjuka

Researcher

E-mail: anna@osi.lv

LinkedIn

Curriculum Vitae

Carrier Latvian Institute of Organic Synthesis, Riga, Latvia
2021 Principal Researcher
2020 Researcher
2007 Research Assistant
2006 Laboratory Assistant

University of Latvia, Faculty of Chemistry, Riga, Latvia
2003 – 2005 Senior Laboratory Assistant
Education 2023 (03) University of Florence, Italy (Prof. C. T. Supuran)
2022 (09-11) HMX Pro Harvard medical School, Certificates of Achievement in Pharmacology; Drug Discovery and Development; Drug Delivery
2022 (05-07) Montpellier University, France (Prof. J.-Y. Winum group)
2019 Dr. Chem., Faculty of Chemistry, University of Latvia
2018 (05-08) PELICO International Project, Enamine Ltd., Ukraine
2016 (04-08) InnovaBalt Exchange Program, University of Oxford, UK (Prof. J. Robertson)
2015 (02-05) InnovaBalt Exchange Program, Universita di Parma, Italy (Prof. G. Costantino)
2007 M.Sc. Chem., Faculty of Chemistry, University of Latvia
2006 Master 2, Universite de Nantes, Faculte Pharmaceutique, France
2004 B.Sc. Chem., Faculty of Chemistry, University of Latvia
Awards 2014 Poster Award, Balticum Organicum Syntheticum, Lithuania
2013 ESMEC Fellowship, 33th Summer School of Medicinal Chemistry, Urbino, Italy

List of Publications

10. Design, Synthesis, and Bioactivity Evaluations of 3-Methylenechroman-2-one Derivatives as Thioredoxin Reductase (TrxR) Inhibitors

Nikitjuka, A.; Ozola, M.; Krims-Davis, K.; Žalubovskis, R. ChemMedChem, 2023, e202300504. DOI:10.1002/cmdc.202300504

9. Boron-containing carbonic anhydrases inhibitors

Giovannuzzi, S.; Nikitjuka, A.; Pereira Resende, B. R.; Smietana, M.; Nocentini, A.; Supuran, C. T.; Winum, J.-Y. Bioorg. Chem., 2024, 143, 106976. DOI:10.1016/j.bioorg.2023.106976

8. Exploration of 3,4-unsubstituted coumarins as thioredoxin reductase 1 inhibitors for cancer therapy

Nikitjuka, A.; Ozola, M.; Jackevica, L.; Bobrovs, R.; Žalubovskis, R. Org. Biomol. Chem., 2023, 21, 9630-9639. DOI:10.1039/D3OB01522J

7. May 1,2-Dithiolane-4-carboxylic Acid and Its Derivatives Serve as a Specific Thioredoxin Reductase 1 Inhibitor?

Nikitjuka, A.; Krims-Davis, K.; Kanepe-Lapsa, I.; Ozola, M.; Žalubovskis, R. Molecules, 2023, 28, 6647. DOI:10.3390/molecules28186647

6. Asparagusic Acid – A Unique Approach toward Effective Cellular Uptake of Therapeutics: Application, Biological Targets, and Chemical Properties

Nikitjuka, A.; Žalubovskis, R. ChemMedChem, 2023, e202300143. DOI:10.1002/cmdc.202300143

5. Refining the Structure−Activity Relationships of 2-Phenylcyclopropane Carboxylic Acids as Inhibitors of O-Acetylserine Sulfhydrylase Isoforms

Magalhães, J.; Franko, N.; Annunziato, G.; Pieroni, M.; Benoni, R.; Nikitjuka, A.; Mozzarelli, A.; Bettati, S.; Karawajczyk, A.; Jirgensons, A.; Campanini, B.; Costantino, G. J. Enzyme Inhib. Med. Chem., 2019, 34, 31-43. DOI:10.1080/14756366.2018.1518959



4. Synthesis and Biological Evaluation of Aziridin-1-yl Oxime-based Vorinostat Analogs as Anticancer Agents

Nikitjuka, A.; Shestakova, I.; Romanchikova, N.; Jirgensons A. Chem. Heterocycl. Compd., 2015, 51(7), 647-657. DOI:10.1007/s10593-015-1752-z



3. Methylprenyl and Prenyl Protection for Sulfonamides

Nikitjuka, A.;  Nekrasova, A.; Jirgensons A. Synlett, 2015,  26, 183-186. DOI:10.1055/s-0034-1379428



2. Synthesis, Chemical and Biological Properties of Aziridine-1-carbaldehyde Oximes (Minireview)

Nikitjuka, A.; Jirgensons, A. Chem. Heterocycl. Compd., 2014, 49, 1544-1559. Dedicated to Professor Janis Stradins on the occasion of his 80 anniversary. DOI:10.1007/s10593-014-1407-5



1. Synthesis of Hydroxamic Acids by Using the Acid Labile O-2-Methylprenyl Protecting Group

Nikitjuka, A; Jirgensons, A. Synlett, 2012, 23, 2972-2974. DOI:10.1055/s-0032-1317687