Curriculum Vitae

Carrier	Latvian Institute of Organic Synthesis, Riga, Latvia Since 2017 Deputy Director of the LIOS for Science Since 2006 Head of Group Since 2004 Principal Researcher 2001 Researcher 1991 Research Assistant Riga Technical University, Riga, Latvia Since 2016 Full Professor 2011 Associate Professor  2007 Docent University of Perugia, Perugia, Italy 2002 (Jan-Dec) Postdoctoral Researcher
Education	2002 (Jan-Dec) Postdoc, University of Perugia (Prof. R. Pellicciari Group) 2000 Dr. Chem., Faculty of Chemistry, University of Latvia 1997 M.Sc. Chem., Faculty of Chemistry, University of Latvia 1995 B.Sc. Chem., Faculty of Chemistry, University of Latvia
Awards	Full Member at Latvian Academy of Science Member of Experts at Latvian Science Council Member of Advisory Board at Latvian Science Council Latvian Representative of EU-OPENSCREEN. Latvian Representative of EuChemS Organic Chemistry Section Field Editor of The Journal “ Amino Acids” 2023 Commander of the Order of the Three Stars 2019 Paul Walden’s medal 2018 G. Vanags Prize in Chemistry from Latvian Academy of Science 2017 Full Member of the Latvian Academy of Science 2016 Scientific Achievement of the Year from Latvian Academy of Science 2001 Merz Pharmaceuticals Postdoctoral Fellowship

List of Publications

100. Discovery and optimisation of pyrazolo[1,5-a]pyrimidines as aryl hydrocarbon receptor antagonists

Bobrovs, R.; Terentjeva, S.; Olafsen, N. E.; Dambrauskas, Z.; Gulbinas, A.; Maimets, T.; Teino, I.; Jirgensons, A.; Matthews, J.; Jaudzems, K. RSC Med. Chem., 2024, 15, 3477-3484. DOI:10.1039/D4MD00266K

99. Repurposing Hsp90 inhibitors as antimicrobials targeting two-component systems identifies compounds leading to loss of bacterial membrane integrity

Fernandez-Ciruelos, B.; Albanese, M.; Adhav, A.; Solomin, V.; Ritchie-Martinez, A.; Taverne, F.; Velikova, N.; Jirgensons, A.; Marina, A.; Finn, P. W.; Wells, J. M. Microbiol. Spectr., 2024, 12, e00146-24. DOI:10.1128/spectrum.00146-24

98. Structural Basis for Inhibition of the SARS-CoV-2 nsp16 by Substrate-Based Dual Site Inhibitors

Kalnins, G.; Rudusa, L.; Bula, A. L.; Zelencova-Gopejenko, D.; Bobileva, O.; Sisovs, M.; Tars, K.; Jirgensons, A.; Jaudzems, K.; Bobrovs, R. ChemMedChem, 2024, 19, e202400618. DOI:10.1002/cmdc.202400618

97. Bioinspired Semisynthesis and Structure Revisions of Chlorinated Norsesquiterpenoids Rumphellatins A–C

Stakanovs G.; Blazevica, A.; Rasina, D.; Belyakov, S.; Jirgensons, A. Org. Lett., 2024, 26, 38, 8074-8078. DOI:10.1021/acs.orglett.4c02942

96. Bridgehead epoxide iso-euphoranin E from β-caryophyllene oxide via sequential cationic formation and scission of [4.3.2]propellane

Stakanovs G.; Rasina, D.; Belyakov, S.; Kinens, A.; Jirgensons, A. Org. Chem. Front., 2024, Advance Article. DOI:10.1039/D4QO00940A

95. Peptidic Boronic Acid Plasmodium falciparum SUB1 Inhibitors with Improved Selectivity over Human Proteasome

Withers-Martinez, C.; Lidumniece, E.; Collins, C. R.; Taha, Z.; Blackman, M. J.; Jirgensons, A. J. Med. Chem. 2024, 67, 13033–13055. DOI:10.1021/acs.jmedchem.4c01005

94. Synthesis of 2-arylquinazolines by Chan–Evans–Lam coupling of 2-formylphenylboronic acids with amidines

Solomin V.V., Zaharova D., Jirgensons A. Chem. Heterocycl. Comp. 2024, 60, 169–174. DOI:10.1007/s10593-024-03314-2

93. Substrate Analogues Entering the Lipoic Acid Salvage Pathway via Lipoate-Protein Ligase 2 Interfere with Staphylococcus aureus Virulence

Scattolini, A.; Grammatoglou, .; Nikitjuka, A.; Jirgensons, A.; Mansilla, M. C.; Windshügel, B. ACS Infect. Dis. 2024, 10, 2172-2182. DOI:10.1021/acsinfecdis.4c00148

92. Design, quality and validation of the EU-OPENSCREEN fragment library poised to a high-throughput screening collection

Jalencas, X.; Berg, H.; Espeland, L. O.; Sreeramulu, S.; Kinnen, F.; Richter, C.; Georgiou, C.; Yadrykhinsky, V.; Specker, E.; Jaudzems, K.; Miletić, T.; Harmel, R.; Gribbon, P.; Schwalbe, H.; Brenk, R.; Jirgensons, A.; Zaliani, A.; Mestres, J. RSC Med. Chem., 2024, 15, 1176-1188. DOI:10.1039/D3MD00724C

91. Structure-based identification of salicylic acid derivatives as malarial threonyl tRNA-synthetase inhibitors

Bobrovs, R.; Bolsakova, J.; Buitrago, J. A. R.; Varaceva, L.; Skvorcova, M.; Kanepe, I.; Rudnickiha, A.; Parisini, E.; Jirgensons, A. PLoS ONE, 2024, 19, e0296995. DOI:10.1371/journal.pone.0296995

90. Spiropyran-Based Photoisomerizable α-Amino Acid for Membrane-Active Peptide Modification

Hrebonkin, A.; Afonin, S.; Nikijuka, A.; Borysov, O. V.; Leitis, G.; Babii, O.; Koniev, S.; Lorig, T.; Grage, S. L.; Nick, P.; Ulrich, A. S.; Jirgensons, A; Komarov, I. V. Chem. – Eur. J., 2024, 30, e202400066. DOI:10.1002/chem.202400066

89. Electrochemical Formation of Oxazolines by 1,3-Oxyfluorination of Non-activated Cyclopropanes

Darzina, M.; Jirgensons, A. Org. Lett., 2024, 26, 2158–2162. DOI:10.1021/acs.orglett.4c00143

88. Discovery of Malarial Threonyl tRNA Synthetase Inhibitors by Screening of a Focused Fragment Library

Bolsakova, J.; Bobrovs, R.; Varacheva, L.; Rudnickiha, A.; Kanepe, I.; Parisini, E.; Jirgensons, A. ACS Med. Chem. Lett. 2024, 15, 76–80. DOI:10.1021/acsmedchemlett.3c00403

83. Assembling the Methanoindene Cage of Phragmalin-Type Natural Products

Becica, J.; Rāciņš, O.; Ivanova, M.; Jirgensons, A. J. Org. Chem., 2023,  88, 10306–10309. DOI:10.1021/acs.joc.3c00952

82. Synthesis and evaluation of an agrocin 84 toxic moiety (TM84) analogue as a malarial threonyl tRNA synthetase inhibitor

Rodriguez Buitrago, J. A.; Leitis, G.; Kaņepe-Lapsa, I.; Rudnickiha, A.;  Parisini, E.; Jirgensons, A. Org. Biomol. Chem., 2023,  21, 5433-5439. DOI:10.1039/D3OB00670K

81. 3-(Adenosylthio)benzoic Acid Derivatives as SARS-CoV-2 Nsp14 Methyltransferase Inhibitorswman

Bobileva, O.; Bobrovs, R.; Sirma, E. E.; Kanepe, I.; Bula, A. L.; Patetko, L.; Ramata-Stunda, A.; Grinberga, S.; Jirgensons, A.; Jaudzems, K. Molecules, 2023, 28(2), 768. DOI:10.3390/molecules28020768

80. Synthesis and SAR of phenylazoles, active against Staphylococcus aureus Newman

Solomin, V. V.; Ciruelos, B. F.; Velikova, N.; Wells, J.; Albanese, M.; Adhav, A.; Jirgensons, A. Chem. Heterocycl. Compd., 2022, 58, 737-748. DOI:10.1007/s10593-023-03151-9

79. Intramolecular Friedel–Crafts alkylation by electrochemical carbenium ion generation

Lielpētere, A.; Šilaks, A.; Jirgensons, A. Chem. Heterocycl. Compd., 2022, 58, 732-736. DOI:10.1007/s10593-023-03150-w

78. Subtilisin-like Serine Protease 1 (SUB1) as an Emerging Antimalarial Drug Target: Current Achievements in Inhibitor Discovery

Lidumniece, E.; Withers-Martinez, C.; Hackett, F.; Blackman, M. J.; Jirgensons, A. J. Med. Chem., 2022, 65, 12535-12545. DOI:10.1021/acs.jmedchem.2c01093

77. Functionalization of Tetrazoles Bearing the Electrochemically Cleavable 1N-(6-Methylpyridyl-2-methyl) Protecting Group

Grammatoglou, K.; Dārziņa, M.; Jirgensons, A. ACS Omega, 2022, 7, 18103–18109. DOI:10.1021/acsomega.2c01633

76. Convergent biomimetic semisynthesis of disesquiterpenoid rumphellolide J

Stakanovs, G.; Belyakov, S.; Jirgensons, A.; Rasina, D. Org. Biomol. Chem., 2022, 20, 2455-246. DOI:10.1039/D2OB00238H

75. Exploring Aspartic Protease Inhibitor Binding to Design Selective Antimalarials

Bobrovs, R.; Basens, E. E.; Drunka, L.; Kanepe, I.; Matisone, S.; Velins, K. K.; Andrianov, V.; Leitis, G.; Zelencova-Gopejenko, D.; Rasina, D.; Jirgensons, A.; Jaudzems, K. J. Chem. Inf. Model., 2022, 62, 3263–3273. DOI:10.1021/acs.jcim.2c00422

74. Functionalization of 1N-Protected Tetrazoles by Deprotonation with the Turbo Grignard Reagent

Grammatoglou, K.; Jirgensons, A. J. Org. Chem., 2022, 87, 3810-3816. DOI:10.1021/acs.joc.1c02926

73. Discovery of sars-cov-2 nsp14 and nsp16 methyltransferase inhibitors by high-throughput virtual screening

Babrovs, R.; Kanepe, I.; Narvaiss, N.; Patetko, L.; Kalnins, G.; Sisovs, M.; Bula, A. L.; Grinberga, S.; Boroduskis, M.; Ramata-Stunda, A.; Rostoks, N.; Jirgensons, A. Pharmaceuticals, 2021, 14, 1243. DOI:10.3390/ph14121243

72. Torii-Type Electrosynthesis of α,β-Unsaturated Esters from Furfurylated Ethylene Glycols and Amino Alcohols

Darzina, M.; Lielpetere, A.; Jirgensons, A. Eur. J. Org. Chem., 2021, 2021, 4224. DOI:10.1002/ejoc.202100605

71. Synthesis of Indazoles From 2-Formylphenylboronic Acids

Solomin, V. V.; Seins, A.; Jirgensons, A. RSC Adv. 2021, 11, 22710-22714. DOI:10.1039/D1RA04056A

70. Potent SARS-CoV-2 mRNA Cap Methyltransferase Inhibitors by Bioisosteric Replacement of Methionine in SAM Cosubstrate

Bobiļeva, O.; Bobrovs, R.; Kaņepe, I.; Patetko, L.; Kalniņš, G.; Šišovs, M.; Bula, A. L.; Grīnberga, S.; Borodušķis, M.; Ramata-Stunda, A.; Rostoks, N.; Jirgensons, A.; Tārs, K.; Jaudzems, K. ACS Med. Chem. Lett. 2021, 12, 1102-1107. DOI:10.1021/acsmedchemlett.1c00140

69. Peptidic boronic acids are potent cell-permeable inhibitors of the malaria parasite egress serine protease SUB1

Lidumniece, E.; Withers-Martinez, C.; Hackett, F.; Collins, C. R.; Perrin, A. J.; Koussis, K.; Bisson, C.; Blackman, M. J.; Jirgensons, A. Proc. Natl. Acad. Sci. U.S.A., 2021, 118, e2022696118. DOI:10.1073/pnas.2022696118

68. Friedel–Crafts Alkylation with Carbenium Ions Generated by Electrochemical Oxidation of Stannylmethyl Ethers

Lielpetere, A.; Jirgensons, A., Eur. J. Org. Chem., 2020, 29, 4510-4516. DOI:10.1002/ejoc.202000568

67. 2-Aminoquinazolines by Chan–Evans–Lam Coupling of Guanidines with (2-Formylphenyl)boronic Acids

Solomin, V. V.; Seins, A.; Jirgensons, A., Synlett, 2020, 31, 1507-1510. DOI:10.1055/s-0040-1707080

66. Synthesis of 2-Aminopyridopyrimidinones and Their Plasmepsin I, II, IV Inhibition Potency

Rasina, D.; Stakanovs, G.; Kanepe-Lapsa, I.; Bobrovs, R.; Jirgensons, A., Chem. Heterocycl. Compd., 2020, 56, 786-792. DOI:10.1007/s10593-020-02731-3

65. A Concise Bioinspired Semisynthesis of Rumphellaones A–C and Their C-8 Epimers from β-Caryophyllene

Stakanovs, G.; Mishnev, A.; Rasina, D.; Jirgensons, A., J. Nat. Prod. 2020, 83, 6, 2004-2009. DOI:10.1021/acs.jnatprod.0c00403

64. Exploiting Structural Dynamics to Design Open-Flap Inhibitors of Malarial Aspartic Proteases

Bobrovs, R.; Jaudzems, K.; Jirgensons, A. J. Med. Chem., 2019, 62, 20, 8931-8950. DOI:10.1021/acs.jmedchem.9b00184

63. A Novel Collaborative Approach to Facilitate Chemical Biology

Brennecke, P.; Rasina, D.; Aubi, O.; Herzog, K.; Landskron, J.; Cautain, B.; Vicente, F.; Quintana, J.; Mestres, J.; Stechmann, B.; Ellinger, B.; Brea, J; Kolanowski, J. L.; Pilarski, R.; Orzaez, M.; Pineda-Lucena, A.; Laraia, L.; Nami, F.; Zielenkiewicz, P.; Paruch, K.; Hansen, E.; Von Kries, J. P.; Neuenschwander, M.; Specker, E.; Bartunek, P.; Simova, S.; Leśnikowski, Z.; Krauss, S.; Lehtiö, L.; Bilitewski, U.; Brönstrup, M.; Taskén, K.; Jirgensons, A.; Lickert, H.; Clausen, M. H.; Andersen, J. H.; Vicent, M. J.; Genilloud, O.; Martinez, A.; Nazaré, M.; Fecke, W.; Gribbon, P.
SLAS Discov., 2019, 24, 398–413. DOI:10.1177/2472555218816276

62. Amination of Carbenium Ions Generated by Directed Protonolysis of Cyclopropane

Skvorcova, M.; Lukasevics, T. L.; Jirgensons, A. J. Org. Chem., 2019,  84, 3780-3792. DOI:10.1021/acs.joc.8b02576

61. Peptidomimetic Plasmepsin Inhibitors with Potent Anti-Malarial Activity and Selectivity Against Cathepsin D

Zogota, R.; Kinena, L.; Withers-Martinez, C.; Blackman, M.J.; Bobrovs, R.; Pantelejevs, T.; Kanepe-Lapsa, I.; Ozola, V.; Jaudzems, K.; Suna, E.; Jirgensons, A. Eur. J. Med. Chem., 2019, 163, 344-352. DOI:10.1016/j.ejmech.2018.11.068

60. Refining the Structure−Activity Relationships of 2-Phenylcyclopropane Carboxylic Acids as Inhibitors of O-Acetylserine Sulfhydrylase Isoforms

Magalhães, J.; Franko, N.; Annunziato, G.; Pieroni, M.; Benoni, R.; Nikitjuka, A.; Mozzarelli, A.; Bettati, S.; Karawajczyk, A.; Jirgensons, A.; Campanini, B.; Costantino, G. J. Enzyme Inhib. Med. Chem., 2019, 34, 31-43. DOI:10.1080/14756366.2018.1518959

59. Azole-Based Non-Peptidomimetic Plasmepsin Inhibitors

Kinena, L.; Leitis, G.; Kanepe-Lapsa, I.; Bobrovs, R.; Jaudzems, K.; Ozola, V.; Suna, E., Jirgensons, A. Arch. Pharm. Chem. Life Sci., 2018, 351, 1800151. DOI:10.1002/ardp.201800151

58. 2-Aminoquinazolin-4(3H)-one Based Plasmepsin Inhibitors with Improved Hydrophilicity and Selectivity

Rasina, D.; Stakanovs, G.; Borysov, O.V.; Pantelejevs, T.; Bobrovs, R.; Kanepe-Lapsa, I.; Tars, K.; Jaudzems, K.; Jirgensons, A. Biorg. Med. Chem., 2018, 26(9), 2488-2500. DOI:10.1016/j.bmc.2018.04.012

57. N-Leucinyl Benzenesulfonamides as Structurally Simplified Leucyl-tRNA Synthetase Inhibitors

Charlton, M.H.; Aleksis, R.; Saint-Leger, A.; Gupta, A; Loza, E.; , Ribas De Pouplana, L.;  Kaula, I.;  Gustina, D.; Madre, M.; Lola, D;  Jaudzems, K.;  Edmund, G.; Randall, C.P.; Kime, L.;  O’Neill, A.J.; Goessens, W.; Jirgensons, A.; Finn, P.W.  ACS Med. Chem. Lett.  2018, 9(2), 84-88. DOI:10.1021/acsmedchemlett.7b00374

56. Carbenium Ion Formation by Fragmentation of Electrochemically Generated Oxonium Ions

Lielpetere, A.; Jirgensons, A. Org. Biomol. Chem., 2018, 16, 5094-5096. DOI:10.1039/c8ob01339j

55. Inhibition of O-Acetylserine Sulfhydrylase by Fluoroalanine Derivatives

Franko, N.; Grammatoglou, K.; Campanini, B.; Costantino, G.; Jirgensons, A.; Mozzarelli, A. J. Enzyme Inhib. Med. Chem., 2018, 33, 1343-1351. DOI:10.1080/14756366.2018.1504040

54. Discovery of Novel Fragments Inhibiting O-Acetylserine Sulphhydrylase by Combining Scaffold Hopping and Ligand–Based Drug Design

Magalhães, J.; Franko, N.; Annunziato, G.; Welch, M.; Dolan, S.K.; Bruno, A.; Mozzarelli, A.; Armao, S.; Jirgensons, A.; Pieroni, M.; Costantino, G.; Campanini, B. J. Enzyme Inhib. Med. Chem., 2018, 33, 1444-1452. DOI:10.1080/14756366.2018.1512596

53. The Ritter Reaction for the Synthesis of Heterocycles (Minireview)

Bolsakova, J.; Jirgensons, A. Chem. Heterocycl. Compd., 2017, 53(11), 1167-1177. DOI:10.1007/s10593-018-2189-y

52. 1-Amino-1-hydroxymethylcyclobutane Derivatives via Intramolecular Amination of Nonclassical Cyclopropylmethyl Cation

Skvorcova, M., Grigorjeva, L., Jirgensons, A. Chem. Heterocycl. Compd., 2017, 53(9), 989-996. DOI:10.1007/s10593-017-2162-1

51. Amide-Group-Directed Protonolysis of Cyclopropane: An Approach to 2,2-Disubstituted Pyrrolidines

Skvorcova, M.; Jirgensons, A. Org. Lett., 2017, 19, 2478-2481. DOI:10.1021/acs.orglett.7b00584

50. N-Sulfonylcarboxamide as an Oxidizing Directing Group for Ruthenium-Catalyzed C–H Activation/Annulation

Petrova, E.; Rasina, D.;  Jirgensons, A. Eur. J. Org. Chem., 2017, 1773-1779. DOI:10.1002/ejoc.201601582

49. Intramolecular Cyclopropylmethylation via Non-Classical Carbocations

Skvorcova, M.; Jirgensons, A. Org. Biomol. Chem., 2017, 15, 6909-6912. DOI:10.1039/C7OB01721A

48. C-Quaternary Alkynyl Glycinols via the Ritter Reaction of Cobalt Complexed Alkynyl Glycols

Grammatoglou, K.; Bolsakova, J.; Jirgensons, A. RSC Adv., 2017, 7, 27530-27537. DOI:10.1039/C7RA03965D

47. Allylic Amination via Acid Catalyzed Leaving Group Activation

Skvorcova, M.; Jirgensons, A. Curr. Green Chem., 2016, 3(2), 145-159. DOI:10.2174/2213346103666160905101423

46. Evaluation of the Characteristics of Leucyl-tRNA Synthetase (LeuRS) Inhibitor AN3365 in Combination with Different Antibiotic Classes

Monteferrante, C.G.; Jirgensons, A.; Varik, V.; Hauryliuk, V.; Goessens, W.H.F.; Hays, J.P. Eur. J. Clin. Microbiol. Infect. Dis., 2016, 35, 1857-1864. DOI:10.1007/s10096-016-2738-1

45. Targeting Multiple Aminoacyl-tRNA Synthetases Overcomes the Resistance Liabilities Associated with Antibacterial Inhibitors Acting on a Single Such Enzyme

Randall, C.; Rasina, D.; Jirgensons, A.; O’Neill, A.J. Antimicrob. Agents Chemother., 2016, 60(10), 6359-6361. DOI:10.1128/AAC.00674-16

44. Crystal Structure of Plasmodium Falciparum Proplasmepsin IV: the Plasticity of Proplasmepsins

Recacha, R.; Jaudzems, K.; Akopjana, I.; Jirgensons, A.; Tars, K.
Acta Cryst., 2016, F72, 659-666. DOI:10.1107/S2053230X16011663

43. A Polymorphism in LeuS Confers Reduced Susceptibility to GSK2251052 in a Clinical Isolate of Staphylococcus Aureus

Gupta, A.; Monteferrante, C.; Rasina, D.; Leitis, G.; Randall, C.P.; Tomlinson, J.H. Jirgensons, A.; Goessens, W.H.F.; Hays, J. P.; O’Neill, A.J. Antimicrob. Agents Chemother., 2016, 60(5), 3219-3221. DOI:10.1128/AAC.02940-15

42. Fragment-Based Discovery of 2-Aminoquinazolin-4(3H)-ones as Novel Class Nonpeptidomimetic Inhibitors of the Plasmepsins I, II, and IV

Rasina, D.;  Otikovs, M.; Leitans, J.; Recacha, R.; Borysov, O.V.;  Kanepe-Lapsa, I.; Domraceva, I.; Pantelejevs, T.;  Tars, K.;  Blackman, M.J.; Jaudzems, K.;  Jirgensons,  A. J. Med. Chem., 2016, 59, 374–387. DOI:10.1021/acs.jmedchem.5b01558

41. Synthesis of α‐Ethynyl Glycines (Microreview)

Bolsakova, J.; Jirgensons, A. Eur. J. Org. Chem., 2016, 27, 4591-4602. DOI:10.1002/ejoc.201600253

40. Synthesis of Alkynyl‐Glycinols by Lewis Acid Catalyzed Propargylic Substitution of Bis‐Imidates

Sirotkina, J.; Grigorjeva, L.; Jirgensons, A. Eur. J. Org. Chem. 2015, 6900-6908. DOI: 10.1002/ejoc.201500937

39. Synthesis and Biological Evaluation of Aziridin-1-yl Oxime-Based Vorinostat Analogs as Anticancer Agents

Nikitjuka, A.; Shestakova, I.; Romanchikova, N.; Jirgensons A. Chem. Heterocycl. Compd., 2015, 51(7), 647-657. DOI:10.1007/s10593-015-1752-z

38. Tetrahydro-1,3-oxazepines via Intramolecular Amination of Cyclopropylmethyl Cation

Skvorcova, M.; Grigorjeva, L.; Jirgensons, A. Org. Lett., 2015, 17, 2902–2904. DOI:10.1021/acs.orglett.5b01014

37. 2-Vinyl Threoninol Derivatives via Acid-Catalyzed Allylic Substitution of Bisimidates

Kumar, V.; Klimovica, K.;  Rasina, D.; Jirgensons A. J. Org. Chem., 2015, 80, 5934–5943. DOI:10.1021/acs.joc.5b00529

36. Unsaturated syn– and anti-1,2-Amino Alcohols by Cyclization of Allylic Bis-trichloroacetimidates. Stereoselectivity Dependence on Substrate Configuration

Grigorjeva,  L.;  Kinens, A.;  Jirgensons,  A. J. Org. Chem., 2015, 80, 920–927. DOI:10.1021/jo502404y

35. Quinoxaline-Based Inhibitors of Malarial Protease PfSUB1

Kher, S.S.; Penzo, M.; Fulle, S.; Ebejer,  J.P.;  Finn, P.W. ; Blackman, M.J.; Jirgensons, A. Chem. Heterocycl. Compd., 2015, 50, 1457-1463. DOI:10.1007/s10593-014-1610-4

34. Structures of Plasmepsin II from Plasmodium Falciparum in Complex with Two Hydroxyethylamine-Based Inhibitors

Recacha, R.; Leitans, J.; Akopjana, I.; Aprupe, L.; Trapencieris, P.; Jaudzems, K.; Jirgensons, A.; Tars, K. Acta Cryst. 2015, F71, 1531-1539. DOI:10.1107/S2053230X15022049

33. Methylprenyl and Prenyl Protection for Sulfonamides

Nikitjuka, A.;  Nekrasova, A.; Jirgensons A. Synlett, 2015,  26, 183-186. DOI:10.1055/s-0034-1379428

32. Substrate Derived Peptidic α-Ketoamides as Inhibitors of the Malarial Protease PfSUB1

Kher, S.S.; Penzo, M.; Fulle, S.; Finn, P.W. ; Blackman, M.J.; Jirgensons, A. Bioorg. Med. Chem. Lett.,  2014, 24(18), 4486-4489. DOI:10.1016/j.bmcl.2014.07.086

31. Semisynthesis of Libiguin A and Its Analogues by Trans-Lactonization of Phragmalin

Grigorjeva, L.; Liepinsh, E.; Razafimahefa, S.; Yahorau, A.; Yahorava, S.; Rasoanaivo, P.; Jirgensons, A.; Wikberg, J.E.S. J. Org. Chem., 2014, 79(9), 4148–4153. DOI:10.1021/jo500318w

30. Plasmepsin Inhibitory Activity and Structure-Guided Optimization of a Potent Hydroxyethylamine-Based Antimalarial Hit

Jaudzems, K.; Tars, K.; Maurops, G.; Ivdra, N.; Otikovs, M.; Leitans, J.; Kanepe-Lapsa, I.; Domraceva, I.; Mutule, I.; Trapencieris, P.; Blackman, M.J.; Jirgensons, A. ACS Med. Chem. Lett., 2014, 5(4), 373–377. DOI:10.1021/ml4004952

29. Synthesis of β-Amino-α-ketoamides (Review)

Kher, S.S.; Jirgensons, A. Curr. Org. Chem., 2014, 18, 2240-2269. DOI:10.2174/1385272819666140818223225

28. Synthesis, Chemical and Biological Properties of Aziridine-1-carbaldehyde Oximes (Minireview)

Nikitjuka, A.; Jirgensons, A. Chem. Heterocycl. Compd., 2014, 49, 1544-1559. Dedicated to Professor Jānis Stradiņš on the occasion of his 80 anniversary. DOI:10.1007/s10593-014-1407-5

27. Unsaturated Amino Alcohols via Cyclization of Allylic Bistrichloroacetimidates

Jirgensons, A.; Grigorjeva, L.; Maleckis, A.; Klimovica, K. Synlett, 2013, 24(18), 2345-2349. DOI:10.1055/s-0033-1338977

26. Synthesis of 5-Substituted 3-Mercapto-1,2,4-triazoles via Suzuki–Miyaura Reaction

Katkevica, S.; Salun, P.; Jirgensons, A. Tetrahedron Lett., 2013, 54, 4524–4525. DOI:10.1016/j.tetlet.2013.06.067

25. Synthesis of Hydroxamic Acids by Using the Acid Labile O-2-Methylprenyl Protecting Group

Nikitjuka, A.; Jirgensons, A. Synlett, 2012, 23, 2972-2974. DOI:10.1055/s-0032-1317687

24. Synthesis of Cyclic N-Tosyliminocarbonates by Lewis Acid Catalysed Allylic Substitution of Trichloroacetimidates

Grigorjeva, L.; Jirgensons, A. Eur. J. Org. Chem., 2012, 27, 5307–5316. DOI:10.1002/ejoc.201200378

23. Plasmodium Subtilisin-like Protease 1 (SUB1): Insights into the Active-Site Structure, Specificity and Function of a Pan-Malaria Drug Target

Withers-Martinez, C.; Suarez, C.; Fulle, S.; Kher, S.; Penzo, M.; Ebejer, J.-P.; Koussis, K.; Hackett, F.; Jirgensons, A.; Finn, P.; Blackman, M.J. Int. J. Parasitol., 2012, 42, 597-612. DOI:10.1016/j.ijpara.2012.04.005

22. Novel Synthesis of 2-Trichloromethyl-4-vinyl-oxazoline and its Derivatization by Ring Cleavage Reactions

Grigorjeva, L.; Maleckis, A.; Klimovica, K.; Skvorcova, M.; Ivdra, N.; Leitis, G.; Jirgensons, A. Chem. Heterocycl. Compd., 2012, 48, 919-924. Dedicated to professor Ivars Kalvinsh on the occasion of his 65th birthday. DOI:10.1007/s10593-012-1077-0

21. C-Quaternary Vinylglycinols by Metal-Catalysed Cyclization of Allylic Bistrichloroacetimidates

Klimovica, K.; Grigorjeva, L.; Maleckis, A.; Popelis, J.; Jirgensons, A. Synlett, 2011, 2849-2851. DOI:10.1055/s-0031-1289537

20. Lewis Acid Catalyzed Intramolecular Allylic Substitution of Bis(trichloroacetimidates): A Versatile Approach to Racemic Unsaturated Amino Acids

Grigorjeva, L.; Jirgensons, A. Eur. J. Org. Chem., 2011, 2421–2425. DOI:10.1002/ejoc.201100060

19. Catalytic Enantioselective Synthesis of 4-Vinyl-2-trichloromethyloxazoline: An Access to Enantioenriched Vinylglycinol Surrogate

Maleckis, A.; Klimovica, K.; Jirgensons, A. J. Org. Chem., 2010, 75, 7897-7900. DOI:10.1021/jo101781y

18. Synthesis of Hydroxamic Acids by Activation of Carboxylic Acids with N,N’-Carbonyldiimidazole: Exploring the Efficiency of the Method

Usachova, N.; Leitis, G.; Jirgensons, A.; Kalvinsh I. Synthetic Comm., 2010, 40, 927–935. DOI:10.1080/00397910903026723

17. Cyclization of Trichloroacetimidates by Olefin Aminopalladation β‐Heteroatom Elimination

Maleckis, A.; Jaunzeme, I.; Jirgensons, A. Eur. J. Org. Chem., 2009, 6407–6412. DOI:10.1002/ejoc.200900917

16. Synthesis of Novel [1-Aziridinyl-(hydroxyimino)methyl]arenes and Their Cytotoxic Activity

Grigorjeva, А.; Jirgensons, A.; Domracheva, I.; Jaschenko, E.; Shestakova, I.; Andrianov, V.; Kalvinsh, I. Chem. Heterocycl. Compd., 2009, 45, 203-213. DOI:10.1007/s10593-009-0245-3

15. Identification of GCP II Inhibitors Based on 4-Arylmethyl-3-(4-carboxyphenyl)-5-hydroxyisoxazole Scaffold

Teus, M.; Jirgensons, A.; Dambrova, M.; Mezhapuke, R.; Parsons, C.G.; Danysz, W. Lett. Drug Des. Discov., 2009, 6, 29-32. DOI:10.2174/157018009787158544

14. Ether-Directed Diastereoselectivity in Catalysed Overman Rearrangement: Comparative Studies of Metal Catalysts

Jaunzeme, I.; Jirgensons, A. Tetrahedron, 2008, 64, 5794-5799. DOI:10.1016/j.tet.2008.03.099

13. Virtual Screening for Selective Allosteric mGluR1 Antagonists and Structure-Activity Relationship Investigations for Coumarine Derivatives

Noeske, T.; Jirgensons, A.; Starchenkovs, I.; Renner, S.; Jaunzeme, I.; Trifanova, D.; Hechenberger, M.; Bauer, T.; Kauss, V.; Parsons, C.G.; Schneider, G.; Weil, T. Chem. Med. Chem., 2007, 2, 1763-1773. DOI:10.1002/cmdc.200700151

12. A Novel Class of Amino-alkylcyclohexanes as Uncompetitive, Fast, Voltage-Dependent, N-Methyl-D-aspartate (NMDA) Receptor Antagonists – in vitro Characterization

Gilling, K.; Jatzke, C.; Wollenburg, C.; Vanejevs, M.; Kauss, V.; Jirgensons, A.; Parsons, C.G. J. Neural. Transm., 2007, 114, 1529-1537. DOI:10.1007/s00702-007-0792-7

11. Synthesis and GCP II Inhibitory Activity of 4[4-(3-Bromobenzyl)-5-hydroxyisoxazol-3-yl]benzoic Acid Heterocyclic Analogs

Teus, M.; Jirgensons, A.; Dambrova, M.; Mezhapuke, R. Chem. Heterocycl. Compd., 2007, 43, 1440-1444. DOI:10.1007/s10593-007-0222-7

10. Effects of NAAG Peptidase Inhibitor 2-PMPA in Model Chronic Pain – Relation to Brain Concentration

Nagel, J.; Belozertseva, I.; Greco, S.; Kashkin, V.; Malyshkin, A.; Jirgensons, A.; Shekunova, E.; Eilbacher, B.; Bespalov, A.; Danysz, W. Neuropharmacology, 2006, 51, 1163-1171. DOI:10.1016/j.neuropharm.2006.07.018

9. Diastereoselectivity in the Overman Rearrangement of O-Cyclohexylideneethylimidates

Jaunzeme, I.; Jirgensons, A.; Kauss, V.; Liepins, E. Tetrahedron Lett., 2006, 3885-3887. DOI:10.1016/j.tetlet.2006.03.174

8. Novel Catalysts for Overman Rearrangement

Jaunzeme, I.; Jirgensons, A. Synlett, 2005, 2984-2986. DOI:10.1055/s-2005-918952

7. Conformationally Constrained Amino Acids: Enantiodivergent Synthesis of All Four Stereoisomers of 2-(Tetrahydrofuran-2-yl)glycine

Jirgensons, A.; Marinozzi, M.; Pellicciari R. Tetrahedron, 2005, 61, 373-377. DOI:10.1016/j.tet.2004.10.091

6. The Synthesis of Potential Neramexane Metabolites: Cis- and Trans-3-amino-1,3,5,5-tetramethylcyclohexane Carboxylic Acids

Trifanova, D.; Trifonova, M.; Jirgensons, A.; Kauss, V.; Pugovich, O.; Kalvinsh, I.; Quack, G. Tetrahedron Lett., 2004, 45, 8145-8147. DOI:10.1016/j.tetlet.2004.09.047

5. Amino-Alkyl-Cyclohexanes as a Novel Class of Uncompetitive NMDA Receptor Antagonists

Danysz, W.; Parsons, C.G.; Jirgensons, A.; Kauss, V.; Tillner, J. Curr. Pharm. Design, 2002, 8, 835-843. DOI:10.2174/1381612024607117

4. A Practical Synthesis of tert-Alkylamines via the Ritter Reaction with Chloroacetonitrile

Jirgensons, A.; Kauss, V.; Kalvinsh, I.; Gold, M.R. Synthesis, 2000, 1709-1712. DOI:10.1055/s-2000-8208

3. Synthesis and Structure – Affinity Relationships of 1,3,5-Alkylsubstituted Cyclohexylamines Binding at NMDA Receptor PCP Site

Jirgensons, A.; Kauss, V.; Kalvinsh, I.; Gold, M.R.; Danysz, W.; Parsons, C.G.; Quack, G. Eur. J. Med. Chem., 2000, 35, 555-565. DOI:10.1016/S02235234(00)00153-7

2. The Synthesis of 3-Amino-3-methylbicyclo[3.3.1]nonanes. Endo-Selectivity in the Ritter Reaction of 1,3,5,7α -Tetramethylbicyclo[3.3.1]nonan-3-ol

Jirgensons, A.; Kauss, V.; Mishnev, A.F.; Kalvinsh, I. J. Chem. Soc., Perkin Trans. 1, 1999, 0, 3527-3530. DOI:10.1039/A904394B

1. A Convenient Reagent for N-Hydroxyguanylation

Jirgensons, A.; Kums, I.; Kauss, V.; Kalvinsh, I. Synth. Comm., 1997, 27, 315-322. DOI:10.1080/00397919708005034

Patent Applications: 20

WIPO: Aigars Jirgensons