December 23, 2018

Prof. Dr. Aigars Jirgensons

Head of Group, Deputy Director of LIOS for Science



Curriculum Vitae

Carrier Latvian Institute of Organic Synthesis, Riga, Latvia
Since 2017 Deputy Director of the LIOS for Science
Since 2006 Head of Group
Since 2004 Principal Researcher
2001 Researcher
1991 Research Assistant

Riga Technical University, Riga, Latvia
Since 2016 Full Professor
2011 Associate Professor 
2007 Docent

University of Perugia, Perugia, Italy
2002 (Jan-Dec) Postdoctoral Researcher
Education 2002 (Jan-Dec) Postdoc, University of Perugia (Prof. R. Pellicciari Group)
2000 Dr. Chem., Faculty of Chemistry, University of Latvia
1997 M.Sc. Chem., Faculty of Chemistry, University of Latvia
1995 B.Sc. Chem., Faculty of Chemistry, University of Latvia
Awards2018 G. Vanags Prize in Chemistry from Latvian Academy of Science
2017 Full Member of the Latvian Academy of Science
2016 Scientific Achievement of the Year from Latvian Academy of Science
2001 Merz Pharmaceuticals Postdoctoral Fellowship

List of Publications

68. Friedel–Crafts Alkylation with Carbenium Ions Generated by Electrochemical Oxidation of Stannylmethyl Ethers

Lielpetere, A.; Jirgensons, A., Eur. J. Org. Chem., 2020, 29, 4510-4516. DOI:10.1002/ejoc.202000568

Graphical abstract: Johnson–Corey–Chaykovsky fluorocyclopropanation of double activated alkenes: scope and limitations

67. 2-Aminoquinazolines by Chan–Evans–Lam Coupling of Guanidines with (2-Formylphenyl)boronic Acids

Solomin, V. V.; Seins, A.; Jirgensons, A., Synlett, 2020, in press. DOI:10.1055/s-0040-1707080

Graphical abstract: Johnson–Corey–Chaykovsky fluorocyclopropanation of double activated alkenes: scope and limitations

66. Synthesis of 2-Aminopyridopyrimidinones and Their Plasmepsin I, II, IV Inhibition Potency

Rasina, D.; Stakanovs, G.; Kanepe-Lapsa, I.; Babrovs, R.; Jirgensons, A., Chem. Heterocycl. Compd., 2020, 56, 786-792. DOI:10.1007/s10593-020-02731-3

Graphical abstract: Johnson–Corey–Chaykovsky fluorocyclopropanation of double activated alkenes: scope and limitations

65. A Concise Bioinspired Semisynthesis of Rumphellaones A–C and Their C-8 Epimers from β-Caryophyllene

Stakanovs, G.; Mishnev, A.; Rasina, D.; Jirgensons, A., J. Nat. Prod. 2020, 83, 6, 2004-2009. DOI:10.1021/acs.jnatprod.0c00403

Graphical abstract: Johnson–Corey–Chaykovsky fluorocyclopropanation of double activated alkenes: scope and limitations

64. Exploiting Structural Dynamics to Design Open-Flap Inhibitors of Malarial Aspartic Proteases

Babrovs, R.; Jaudzems, K.; Jirgensons, A. J. Med. Chem., 2019, 62, 20, 8931-8950. DOI:10.1021/acs.jmedchem.9b00184

63. A Novel Collaborative Approach to Facilitate Chemical Biology

Brennecke, P.; Rasina, D.; Aubi, O.; Herzog, K.; Landskron, J.; Cautain, B.; Vicente, F.; Quintana, J.; Mestres, J.; Stechmann, B.; Ellinger, B.; Brea, J; Kolanowski, J. L.; Pilarski, R.; Orzaez, M.; Pineda-Lucena, A.; Laraia, L.; Nami, F.; Zielenkiewicz, P.; Paruch, K.; Hansen, E.; Von Kries, J. P.; Neuenschwander, M.; Specker, E.; Bartunek, P.; Simova, S.; Leśnikowski, Z.; Krauss, S.; Lehtiö, L.; Bilitewski, U.; Brönstrup, M.; Taskén, K.; Jirgensons, A.; Lickert, H.; Clausen, M. H.; Andersen, J. H.; Vicent, M. J.; Genilloud, O.; Martinez, A.; Nazaré, M.; Fecke, W.; Gribbon, P.
SLAS Discov., 2019, 24, 398–413. DOI:10.1177/2472555218816276

62. Amination of Carbenium Ions Generated by Directed Protonolysis of Cyclopropane

Skvorcova, M.; Lukasevics, T. L.; Jirgensons, A. J. Org. Chem., 2019 84, 3780-3792. DOI:10.1021/acs.joc.8b02576

61. Peptidomimetic Plasmepsin Inhibitors with Potent Anti-Malarial Activity and Selectivity Against Cathepsin D

Zogota, R.; Kinena, L.; Withers-Martinez, C.; Blackman, M.J.; Bobrovs, R.; Pantelejevs, T.; Kanepe-Lapsa, I.; Ozola, V.; Jaudzems, K.; Suna, E.; Jirgensons, A. Eur. J. Med. Chem., 2019, 163, 344-352. DOI:10.1016/j.ejmech.2018.11.068

60. Refining the Structure−Activity Relationships of 2-Phenylcyclopropane Carboxylic Acids as Inhibitors of O-Acetylserine Sulfhydrylase Isoforms

Magalhães, J.; Franko, N.; Annunziato, G.; Pieroni, M.; Benoni, R.; Nikitjuka, A.; Mozzarelli, A.; Bettati, S.; Karawajczyk, A.; Jirgensons, A.; Campanini, B.; Costantino, G. J. Enzyme Inhib. Med. Chem., 2019, 34, 31-43. DOI:10.1080/14756366.2018.1518959

59. Azole-Based Non-Peptidomimetic Plasmepsin Inhibitors

Kinena, L.; Leitis, G.; Kanepe-Lapsa, I.; Bobrovs, R.; Jaudzems, K.; Ozola, V.; Suna, E., Jirgensons, A. Arch. Pharm. Chem. Life Sci., 2018, 351, 1800151. DOI:10.1002/ardp.201800151

58. 2-Aminoquinazolin-4(3H)-one Based Plasmepsin Inhibitors with Improved Hydrophilicity and Selectivity

Rasina, D.; Stakanovs, G.; Borysov, O.V.; Pantelejevs, T.; Bobrovs, R.; Kanepe-Lapsa, I.; Tars, K.; Jaudzems, K.; Jirgensons, A. Biorg. Med. Chem., 2018, 26(9), 2488-2500. DOI:10.1016/j.bmc.2018.04.012

57. N-Leucinyl Benzenesulfonamides as Structurally Simplified Leucyl-tRNA Synthetase Inhibitors

Charlton, M.H.; Aleksis, R.; Saint-Leger, A.; Gupta, A; Loza, E.; , Ribas De Pouplana, L.;  Kaula, I.;  Gustina, D.; Madre, M.; Lola, D;  Jaudzems, K.;  Edmund, G.; Randall, C.P.; Kime, L.;  O’Neill, A.J.; Goessens, W.; Jirgensons, A.; Finn, P.W.  ACS Med. Chem. Lett.  2018, 9(2), 84-88. DOI:10.1021/acsmedchemlett.7b00374

56. Carbenium Ion Formation by Fragmentation of Electrochemically Generated Oxonium Ions

Lielpetere, A.; Jirgensons, A. Org. Biomol. Chem., 2018, 16, 5094-5096. DOI:10.1039/c8ob01339j

55. Inhibition of O-Acetylserine Sulfhydrylase by Fluoroalanine Derivatives

Franko, N.; Grammatoglou, K.; Campanini, B.; Costantino, G.; Jirgensons, A.; Mozzarelli, A. J. Enzyme Inhib. Med. Chem., 2018, 33, 1343-1351. DOI:10.1080/14756366.2018.1504040

54. Discovery of Novel Fragments Inhibiting O-Acetylserine Sulphhydrylase by Combining Scaffold Hopping and Ligand–Based Drug Design

Magalhães, J.; Franko, N.; Annunziato, G.; Welch, M.; Dolan, S.K.; Bruno, A.; Mozzarelli, A.; Armao, S.; Jirgensons, A.; Pieroni, M.; Costantino, G.; Campanini, B. J. Enzyme Inhib. Med. Chem., 2018, 33, 1444-1452. DOI:10.1080/14756366.2018.1512596

53. The Ritter Reaction for the Synthesis of Heterocycles (Minireview)

Bolsakova, J.; Jirgensons, A. Chem. Heterocycl. Compd., 2017, 53(11), 1167-1177. DOI:10.1007/s10593-018-2189-y

52. 1-Amino-1-hydroxymethylcyclobutane Derivatives via Intramolecular Amination of Nonclassical Cyclopropylmethyl Cation

Skvorcova, M., Grigorjeva, L., Jirgensons, A. Chem. Heterocycl. Compd., 2017, 53(9), 989-996. DOI:10.1007/s10593-017-2162-1

51. Amide-Group-Directed Protonolysis of Cyclopropane: An Approach to 2,2-Disubstituted Pyrrolidines

Skvorcova, M.; Jirgensons, A. Org. Lett., 2017, 19, 2478-2481. DOI:10.1021/acs.orglett.7b00584

50. N-Sulfonylcarboxamide as an Oxidizing Directing Group for Ruthenium-Catalyzed C–H Activation/Annulation

Petrova, E.; Rasina, D.;  Jirgensons, A. Eur. J. Org. Chem., 2017, 1773-1779. DOI:10.1002/ejoc.201601582

49. Intramolecular Cyclopropylmethylation via Non-Classical Carbocations

Skvorcova, M.; Jirgensons, A. Org. Biomol. Chem., 2017, 15, 6909-6912. DOI:10.1039/C7OB01721A

48. C-Quaternary Alkynyl Glycinols via the Ritter Reaction of Cobalt Complexed Alkynyl Glycols

Grammatoglou, K.; Bolsakova, J.; Jirgensons, A. RSC Adv., 2017, 7, 27530-27537. DOI:10.1039/C7RA03965D

47. Allylic Amination via Acid Catalyzed Leaving Group Activation

Skvorcova, M.; Jirgensons, A. Curr. Green Chem., 2016, 3(2), 145-159. DOI:10.2174/2213346103666160905101423

46. Evaluation of the Characteristics of Leucyl-tRNA Synthetase (LeuRS) Inhibitor AN3365 in Combination with Different Antibiotic Classes

Monteferrante, C.G.; Jirgensons, A.; Varik, V.; Hauryliuk, V.; Goessens, W.H.F.; Hays, J.P. Eur. J. Clin. Microbiol. Infect. Dis., 2016, 35, 1857-1864. DOI:10.1007/s10096-016-2738-1

45. Targeting Multiple Aminoacyl-tRNA Synthetases Overcomes the Resistance Liabilities Associated with Antibacterial Inhibitors Acting on a Single Such Enzyme

Randall, C.; Rasina, D.; Jirgensons, A.; O’Neill, A.J. Antimicrob. Agents Chemother., 2016, 60(10), 6359-6361. DOI:10.1128/AAC.00674-16

44. Crystal Structure of Plasmodium Falciparum Proplasmepsin IV: the Plasticity of Proplasmepsins

Recacha, R.; Jaudzems, K.; Akopjana, I.; Jirgensons, A.; Tars, K.
Acta Cryst., 2016, F72, 659-666. DOI:10.1107/S2053230X16011663

43. A Polymorphism in LeuS Confers Reduced Susceptibility to GSK2251052 in a Clinical Isolate of Staphylococcus Aureus

Gupta, A.; Monteferrante, C.; Rasina, D.; Leitis, G.; Randall, C.P.; Tomlinson, J.H. Jirgensons, A.; Goessens, W.H.F.; Hays, J. P.; O’Neill, A.J. Antimicrob. Agents Chemother., 2016, 60(5), 3219-3221. DOI:10.1128/AAC.02940-15

42. Fragment-Based Discovery of 2-Aminoquinazolin-4(3H)-ones as Novel Class Nonpeptidomimetic Inhibitors of the Plasmepsins I, II, and IV

Rasina, D.;  Otikovs, M.; Leitans, J.; Recacha, R.; Borysov, O.V.;  Kanepe-Lapsa, I.; Domraceva, I.; Pantelejevs, T.;  Tars, K.;  Blackman, M.J.; Jaudzems, K.;  Jirgensons,  A. J. Med. Chem., 2016, 59, 374–387. DOI:10.1021/acs.jmedchem.5b01558

41. Synthesis of α‐Ethynyl Glycines (Microreview)

Bolsakova, J.; Jirgensons, A. Eur. J. Org. Chem., 2016, 27, 4591-4602. DOI:10.1002/ejoc.201600253

40. Synthesis of Alkynyl‐Glycinols by Lewis Acid Catalyzed Propargylic Substitution of Bis‐Imidates

Sirotkina, J.; Grigorjeva, L.; Jirgensons, A. Eur. J. Org. Chem. 2015, 6900-6908. DOI: 10.1002/ejoc.201500937

39. Synthesis and Biological Evaluation of Aziridin-1-yl Oxime-Based Vorinostat Analogs as Anticancer Agents

Nikitjuka, A.; Shestakova, I.; Romanchikova, N.; Jirgensons A. Chem. Heterocycl. Compd., 2015, 51(7), 647-657. DOI:10.1007/s10593-015-1752-z

38. Tetrahydro-1,3-oxazepines via Intramolecular Amination of Cyclopropylmethyl Cation

Skvorcova, M.; Grigorjeva, L.; Jirgensons, A. Org. Lett., 2015, 17, 2902–2904. DOI:10.1021/acs.orglett.5b01014

37. 2-Vinyl Threoninol Derivatives via Acid-Catalyzed Allylic Substitution of Bisimidates

Kumar, V.; Klimovica, K.;  Rasina, D.; Jirgensons A. J. Org. Chem., 2015, 80, 5934–5943. DOI:10.1021/acs.joc.5b00529

36. Unsaturated syn– and anti-1,2-Amino Alcohols by Cyclization of Allylic Bis-trichloroacetimidates. Stereoselectivity Dependence on Substrate Configuration

Grigorjeva,  L.;  Kinens, A.;  Jirgensons,  A. J. Org. Chem., 2015, 80, 920–927. DOI:10.1021/jo502404y

35. Quinoxaline-Based Inhibitors of Malarial Protease PfSUB1

Kher, S.S.; Penzo, M.; Fulle, S.; Ebejer,  J.P.;  Finn, P.W. ; Blackman, M.J.; Jirgensons, A. Chem. Heterocycl. Compd., 2015, 50, 1457-1463. DOI:10.1007/s10593-014-1610-4

34. Structures of Plasmepsin II from Plasmodium Falciparum in Complex with Two Hydroxyethylamine-Based Inhibitors

Recacha, R.; Leitans, J.; Akopjana, I.; Aprupe, L.; Trapencieris, P.; Jaudzems, K.; Jirgensons, A.; Tars, K. Acta Cryst. 2015. F71, 1531-1539. DOI:10.1107/S2053230X15022049

33. Methylprenyl and Prenyl Protection for Sulfonamides

Nikitjuka, A.;  Nekrasova, A.; Jirgensons A. Synlett, 2015,  26, 183-186. DOI:10.1055/s-0034-1379428

32. Substrate Derived Peptidic α-Ketoamides as Inhibitors of the Malarial Protease PfSUB1

Kher, S.S.; Penzo, M.; Fulle, S.; Finn, P.W. ; Blackman, M.J.; Jirgensons, A. Bioorg. Med. Chem. Lett.,  2014, 24(18), 4486-4489. DOI:10.1016/j.bmcl.2014.07.086

31. Semisynthesis of Libiguin A and Its Analogues by Trans-Lactonization of Phragmalin

Grigorjeva, L.; Liepinsh, E.; Razafimahefa, S.; Yahorau, A.; Yahorava, S.; Rasoanaivo, P.; Jirgensons, A.; Wikberg, J.E.S. J. Org. Chem., 2014, 79(9), 4148–4153. DOI:10.1021/jo500318w

30. Plasmepsin Inhibitory Activity and Structure-Guided Optimization of a Potent Hydroxyethylamine-Based Antimalarial Hit

Jaudzems, K.; Tars, K.; Maurops, G.; Ivdra, N.; Otikovs, M.; Leitans, J.; Kanepe-Lapsa, I.; Domraceva, I.; Mutule, I.; Trapencieris, P.; Blackman, M.J.; Jirgensons, A. ACS Med. Chem. Lett., 2014, 5(4), 373–377. DOI:10.1021/ml4004952

29. Synthesis of β-Amino-α-ketoamides (Review)

Kher, S.S.; Jirgensons, A. Curr. Org. Chem., 2014, 18, 2240-2269. DOI:10.2174/1385272819666140818223225

28. Synthesis, Chemical and Biological Properties of Aziridine-1-carbaldehyde Oximes (Minireview)

Nikitjuka, A.; Jirgensons, A. Chem. Heterocycl. Compd., 2014, 49, 1544-1559. Dedicated to Professor Jānis Stradiņš on the occasion of his 80 anniversary. DOI:10.1007/s10593-014-1407-5

27. Unsaturated Amino Alcohols via Cyclization of Allylic Bistrichloroacetimidates

Jirgensons, A.; Grigorjeva, L.; Maleckis, A.; Klimovica, K. Synlett, 2013, 24(18), 2345-2349. DOI:10.1055/s-0033-1338977

26. Synthesis of 5-Substituted 3-Mercapto-1,2,4-triazoles via Suzuki–Miyaura Reaction

Katkevica, S.; Salun, P.; Jirgensons, A. Tetrahedron Lett., 2013, 54, 4524–4525. DOI:10.1016/j.tetlet.2013.06.067

25. Synthesis of Hydroxamic Acids by Using the Acid Labile O-2-Methylprenyl Protecting Group

Nikitjuka, A.; Jirgensons, A. Synlett, 2012, 23, 2972-2974. DOI:10.1055/s-0032-1317687

24. Synthesis of Cyclic N-Tosyliminocarbonates by Lewis Acid Catalysed Allylic Substitution of Trichloroacetimidates

Grigorjeva, L.; Jirgensons, A. Eur. J. Org. Chem., 2012, 27, 5307–5316. DOI:10.1002/ejoc.201200378

23. Plasmodium Subtilisin-like Protease 1 (SUB1): Insights into the Active-Site Structure, Specificity and Function of a Pan-Malaria Drug Target

Withers-Martinez, C.; Suarez, C.; Fulle, S.; Kher, S.; Penzo, M.; Ebejer, J.-P.; Koussis, K.; Hackett, F.; Jirgensons, A.; Finn, P.; Blackman, M.J. Int. J. Parasitol., 2012, 42, 597-612. DOI:10.1016/j.ijpara.2012.04.005

22. Novel Synthesis of 2-Trichloromethyl-4-vinyl-oxazoline and its Derivatization by Ring Cleavage Reactions

Grigorjeva, L.; Maleckis, A.; Klimovica, K.; Skvorcova, M.; Ivdra, N.; Leitis, G.; Jirgensons, A. Chem. Heterocycl. Compd., 2012, 48, 919-924. Dedicated to professor Ivars Kalvinsh on the occasion of his 65th birthday. DOI:10.1007/s10593-012-1077-0

21. C-Quaternary Vinylglycinols by Metal-Catalysed Cyclization of Allylic Bistrichloroacetimidates

Klimovica, K.; Grigorjeva, L.; Maleckis, A.; Popelis, J.; Jirgensons, A. Synlett, 2011, 2849-2851. DOI:10.1055/s-0031-1289537

20. Lewis Acid Catalyzed Intramolecular Allylic Substitution of Bis(trichloroacetimidates): A Versatile Approach to Racemic Unsaturated Amino Acids

Grigorjeva, L.; Jirgensons, A. Eur. J. Org. Chem., 2011, 2421–2425. DOI:10.1002/ejoc.201100060

19. Catalytic Enantioselective Synthesis of 4-Vinyl-2-trichloromethyloxazoline: An Access to Enantioenriched Vinylglycinol Surrogate

Maleckis, A.; Klimovica, K.; Jirgensons, A. J. Org. Chem., 2010, 75, 7897-7900. DOI:10.1021/jo101781y

18. Synthesis of Hydroxamic Acids by Activation of Carboxylic Acids with N,N’-Carbonyldiimidazole: Exploring the Efficiency of the Method

Usachova, N.; Leitis, G.; Jirgensons, A.; Kalvinsh I. Synthetic Comm., 2010, 40, 927–935. DOI:10.1080/00397910903026723

17. Cyclization of Trichloroacetimidates by Olefin Aminopalladation β‐Heteroatom Elimination

Maleckis, A.; Jaunzeme, I.; Jirgensons, A. Eur. J. Org. Chem., 2009, 6407–6412. DOI:10.1002/ejoc.200900917

16. Synthesis of Novel [1-Aziridinyl-(hydroxyimino)methyl]arenes and Their Cytotoxic Activity

Grigorjeva, А.; Jirgensons, A.; Domracheva, I.; Jaschenko, E.; Shestakova, I.; Andrianov, V.; Kalvinsh, I. Chem. Heterocycl. Compd., 2009, 45, 203-213. DOI:10.1007/s10593-009-0245-3

15. Identification of GCP II Inhibitors Based on 4-Arylmethyl-3-(4-carboxyphenyl)-5-hydroxyisoxazole Scaffold

Teus, M.; Jirgensons, A.; Dambrova, M.; Mezhapuke, R.; Parsons, C.G.; Danysz, W. Lett. Drug Des. Discov., 2009, 6, 29-32. DOI:10.2174/157018009787158544

14. Ether-Directed Diastereoselectivity in Catalysed Overman Rearrangement: Comparative Studies of Metal Catalysts

Jaunzeme, I.; Jirgensons, A. Tetrahedron, 2008, 64, 5794-5799. DOI:10.1016/j.tet.2008.03.099

13. Virtual Screening for Selective Allosteric mGluR1 Antagonists and Structure-Activity Relationship Investigations for Coumarine Derivatives

Noeske, T.; Jirgensons, A.; Starchenkovs, I.; Renner, S.; Jaunzeme, I.; Trifanova, D.; Hechenberger, M.; Bauer, T.; Kauss, V.; Parsons, C.G.; Schneider, G.; Weil, T. Chem. Med. Chem., 2007, 2, 1763-1773. DOI:10.1002/cmdc.200700151

12. A Novel Class of Amino-alkylcyclohexanes as Uncompetitive, Fast, Voltage-Dependent, N-Methyl-D-aspartate (NMDA) Receptor Antagonists – in vitro Characterization

Gilling, K.; Jatzke, C.; Wollenburg, C.; Vanejevs, M.; Kauss, V.; Jirgensons, A.; Parsons, C.G. J. Neural. Transm., 2007, 114, 1529-1537. DOI:10.1007/s00702-007-0792-7

11. Synthesis and GCP II Inhibitory Activity of 4[4-(3-Bromobenzyl)-5-hydroxyisoxazol-3-yl]benzoic Acid Heterocyclic Analogs

Teus, M.; Jirgensons, A.; Dambrova, M.; Mezhapuke, R. Chem. Heterocycl. Compd., 2007, 43, 1440-1444. DOI:10.1007/s10593-007-0222-7

10. Effects of NAAG Peptidase Inhibitor 2-PMPA in Model Chronic Pain – Relation to Brain Concentration

Nagel, J.; Belozertseva, I.; Greco, S.; Kashkin, V.; Malyshkin, A.; Jirgensons, A.; Shekunova, E.; Eilbacher, B.; Bespalov, A.; Danysz, W. Neuropharmacology, 2006, 51, 1163-1171. DOI:10.1016/j.neuropharm.2006.07.018

9. Diastereoselectivity in the Overman Rearrangement of O-Cyclohexylideneethylimidates

Jaunzeme, I.; Jirgensons, A.; Kauss, V.; Liepins, E. Tetrahedron Lett., 2006, 3885-3887. DOI:10.1016/j.tetlet.2006.03.174

8. Novel Catalysts for Overman Rearrangement

Jaunzeme, I.; Jirgensons, A. Synlett, 2005, 2984-2986. DOI:10.1055/s-2005-918952

7. Conformationally Constrained Amino Acids: Enantiodivergent Synthesis of All Four Stereoisomers of 2-(Tetrahydrofuran-2-yl)glycine

Jirgensons, A.; Marinozzi, M.; Pellicciari R. Tetrahedron, 2005, 61, 373-377. DOI:10.1016/j.tet.2004.10.091

6. The Synthesis of Potential Neramexane Metabolites: Cis- and Trans-3-amino-1,3,5,5-tetramethylcyclohexane Carboxylic Acids

Trifanova, D.; Trifonova, M.; Jirgensons, A.; Kauss, V.; Pugovich, O.; Kalvinsh, I.; Quack, G. Tetrahedron Lett., 2004, 45, 8145-8147. DOI:10.1016/j.tetlet.2004.09.047

5. Amino-Alkyl-Cyclohexanes as a Novel Class of Uncompetitive NMDA Receptor Antagonists

Danysz, W.; Parsons, C.G.; Jirgensons, A.; Kauss, V.; Tillner, J. Curr. Pharm. Design, 2002, 8, 835-843. DOI:10.2174/1381612024607117

4. A Practical Synthesis of tert-Alkylamines via the Ritter Reaction with Chloroacetonitrile

Jirgensons, A.; Kauss, V.; Kalvinsh, I.; Gold, M.R. Synthesis, 2000, 1709-1712DOI:10.1055/s-2000-8208

3. Synthesis and Structure – Affinity Relationships of 1,3,5-Alkylsubstituted Cyclohexylamines Binding at NMDA Receptor PCP Site

Jirgensons, A.; Kauss, V.; Kalvinsh, I.; Gold, M.R.; Danysz, W.; Parsons, C.G.; Quack, G. Eur. J. Med. Chem., 2000, 35, 555-565. DOI:10.1016/S02235234(00)00153-7

2. The Synthesis of 3-Amino-3-methylbicyclo[3.3.1]nonanes. Endo-Selectivity in the Ritter Reaction of 1,3,5,7α -Tetramethylbicyclo[3.3.1]nonan-3-ol

Jirgensons, A.; Kauss, V.; Mishnev, A.F.; Kalvinsh, I. J. Chem. Soc., Perkin Trans. 1, 1999, 0, 3527-3530. DOI:10.1039/A904394B

1. A Convenient Reagent for N-Hydroxyguanylation

Jirgensons, A.; Kums, I.; Kauss, V.; Kalvinsh, I. Synth. Comm., 1997, 27, 315-322. DOI:10.1080/00397919708005034

Patent Applications: 20

WIPO: Aigars Jirgensons