January 10, 2019

Dr. Ansis Maleckis

Principal Researcher, Project Leader

E-mail: maleckis@umich.edu

Curriculum Vitae

Latvian Institute of Organic Synthesis, Riga, Latvia
Since 2019 Principal Researcher
2014 Researcher
2009 Research Assistant
2007 Laboratory Assistant

University of Michigan, Ann Arbor, USA
2010-2014 Research Assistant

Australian National University, Canberra, Australia
2009-2010 Visiting Scholar

Riga Technical University, Riga, Latvia
2004-2007 Laboratory Assistant
Education 2014 Ph.D. Chem., University of Michigan, Ann Arbor, USA (Prof. M.S. Sanford Group)
2009 M.Sc.Ing. Chem.,  Faculty of Materials Science and Applied Chemistry,  Riga Technical University  
2007 B.Sc. Chem.,  Faculty of Materials Science and Applied Chemistry,  Riga Technical University
Awards2013 Howard Hughes Medical Institute International Student Research Fellowship
2011 Member of The Honor Society of Phi Kappa Phi
2010  Latvian Academy of Science, Martins Straumanis–Alfreds Ievins Award for the Master Thesis
2006 Kristaps Morbergs Scholarship


List of Publications

18. Synthesis of 13C/19F/2H labeled indoles for use as tryptophan precursors for protein NMR spectroscopy

Maleckis, A.; Herath, I. D.; Otting, G. Org. Biomol. Chem., 2021, 19, 5133-5147. DOI:10.1039/D1OB00611H

17. Cell‐Free Synthesis of Selenoproteins in High Yield and Purity for Selective Protein Tagging

Welegedara, A. P.; Maleckis, A.; Bandara, R.; Mahawaththa, M. C.; Herath, I. D.; Tan, Y. J.; Giannoulis, A.; Goldfarb, D.; Otting, G.; Huber, T. ChemBioChem, 2021, 22, 1480-1486. DOI:10.1002/cbic.202000785

Graphical abstract: Johnson–Corey–Chaykovsky fluorocyclopropanation of double activated alkenes: scope and limitations

16. Synthesis of Fluoroalkyl Palladium and Nickel Complexes via Decarbonylation of Acylmetal Species

Maleckis, A.; Sanford, M.S. Organometallics, 2014, 33(14), 3831–3839. DOI:10.1021/om500535x

15. Catalytic Cycle for Palladium-Catalyzed Decarbonylative Trifluoromethylation using Trifluoroacetic Esters as the CF3 Source

Maleckis, A.; Sanford, M.S. Organometallics, 2014, 33(10), 2653–2660. DOI:10.1021/om500398z

14. A Detailed Study of Acetate-Assisted C–H Activation at Palladium(IV) Centers

Maleckis, A.; Kampf, J.W.; Sanford, M.S. J. Am. Chem. Soc., 2013, 135, 6618-6625. DOI:10.1021/ja401557

13. Three-Dimensional Protein Fold Determination from Backbone Amide Pseudocontact Shifts Generated by Lanthanide Tags at Multiple Site

Yagi, H.; Pilla, K.B.; Maleckis, A.; Graham, B.; Huber, T.; Otting, G. Structure, 2013, 21, 883-890. DOI:10.1016/j.str.2013.04.001

12. A Systematic Study of Labelling an α-Helix in a Protein with a Lanthanide Using IDA-SH or NTA-SH Tags

Yagi, H.; Maleckis, A.; Otting, G. J. Biomol. NMR., 2013, 55, 157-166. DOI:10.1007/s10858-012-9697-3

11. Unsaturated Amino Alcohols via Cyclization of Allylic Bistrichloroacetimidates

Jirgensons, A.; Grigorjeva, L.; Maleckis, A.; Klimovica, K. Synlett, 2013, 24(18), 2345-2349. DOI:10.1055/s-0033-1338977

10. Thiol–Ene Reaction: A Versatile Tool in Site-Specific Labelling of Proteins with Chemically Inert Tags for Paramagnetic NMR

Li, Q.-F.; Yang, Y.; Maleckis, A.; Otting, G.; Su, X.-C. Chem. Commun., 2012, 48, 2704-2706. DOI:10.1039/C2CC17900H

9. Novel Synthesis of 2-Trichloromethyl-4-vinyl-oxazoline and its Derivatization by Ring Cleavage Reactions

Grigorjeva, L.; Maleckis, A.; Klimovica, K.; Skvorcova, M.; Ivdra, N.; Leitis, G.; Jirgensons, A. Chem. Heterocycl. Compd., 2012, 48, 919-924. Dedicated to professor Ivars Kalvinsh on the occasion of his 65th birthday. DOI:10.1007/s10593-012-1077-0

8. Facial Tridentate Ligands for Stabilizing Palladium(IV) Complexes

Maleckis, A.; Sanford, M.S. Organometallics, 2011, 30(24), 6617-6627. DOI:10.1021/om200779j

7. Engineering of a Bis-Chelator Motif into a Protein α-Helix for Rigid Lanthanide Binding and Paramagnetic NMR Spectroscopy

Swarbrick, J.D.; Ung, P.; Su, X.C.; Maleckis, A.; Chhabra S.; Huber, T.; Otting, G.; Graham, G. Chem. Commun., 2011, 47, 7368-7370. DOI:10.1039/C1CC11893E

6. 4,4′‐Dithiobisdipicolinic Acid: A Small and Convenient Lanthanide Binding Tag for Protein NMR Spectroscopy

Jia, X.; Maleckis, A.; Huber, T.; Otting, G. Chem. Eur. J., 2011, 17, 6830-6836. DOI:10.1002/chem.201003573

5. C-Quaternary Vinylglycinols by Metal Catalysed Cyclization of Allylic Bis-Trichloroacetimidates

Klimovica, K.; Grigorjeva, L.; Maleckis, A.; Popelis, J.; Jirgensons, A. Synlett, 2011, 2849-2851. DOI:10.1055/s-0031-1289537

4. Catalytic Enantioselective Synthesis of 4-Vinyl-2-trichloromethyloxazoline: An Access to Enantioenriched Vinylglycinol Surrogate

Maleckis, A.; Klimovica, K.; Jirgensons, A. J. Org. Chem., 2010, 75, 7897-7900. DOI:10.1021/jo101781y

3. Cyclization of Trichloroacetimidates by Olefin Aminopalladation β‐Heteroatom Elimination

Maleckis, A.; Jaunzeme, I.; Jirgensons, A. Eur. J. Org. Chem., 2009, 6407–6412. DOI:10.1002/ejoc.200900917

2. Green and Red Laser Holographic Recording in Different Glassy Azocompounds

Ozols, A.; Kokars, V.; Augustovs, P.; Traskovskis, K.; Maleckis, A.; Mezinskis, G.; Pludons, A.; Saharov, D. Opt. Mater., 2010, 32, 811-817. DOI:10.1016/j.optmat.2010.01.022

1. Holographic Recording of Surface Relief Gratings in Stilbene Azobenzene Derivatives at 633 nm

Ozols, A.; Saharov, D.; Kokars, V.; Kampars, V.; Maleckis, A.; Mezinskis, G; Pludons, A. J. Phys. Conf. Ser., 2010, 249, 012055. DOI:10.1088/1742-6596/249/1/012055