January 10, 2019

Dr. Liene Grigorjeva

Principal Researcher, Project Leader

E-mail: liene_grigorjeva@osi.lv

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Curriculum Vitae

Carrier Latvian Institute of Organic Synthesis, Riga, Latvia
Since 2018 Principal Researcher
2016 Researcher
2009 Research Assistant
2006 Laboratory Assistant

Riga Technical University, Riga, Latvia
Since 2019 Assistant Professor

University of Houston, Houston, USA
2013-2016 Postdoctoral Researcher
Education 2013-2016 Postdoc, University of Houston, USA (Prof. O. Daugulis Group)
2013 Dr. Chem., Faculty of Materials Science and Applied Chemistry, Riga Technical University
2009 M.Sc.Ing. Chem., Faculty of Materials Science and Applied Chemistry,  Riga Technical University  
2007 B.Sc. Chem., Faculty of Materials Science and Applied Chemistry,  Riga Technical University
Awards2023 Corresponding member of the Latvian Academy of Sciences
2023 L’Oreal-UNESCO For Women in Science Young Talent Award (program Baltic)
2023 RSC Certificate of appreciation Higly cited article (Chem. Commun., 2021, 57, 83, 10827)
2019 Member of Experts at Latvian Science Council
2016 Chemistry Science Doctoral Award Named After Solomon Hiller
2014 Latvian Institute of Organic Synthesis, E. Lukevics Award for the PhD Thesis
2013 ESF Scholarship for PhD students
2011  LLC “Bapeks” Poster Award in 7th Paul Walden Symposium on Organic Chemistry
2010  Latvian Academy of Science, Martins Straumanis–Alfreds Ievins Award for the Master Thesis
2004–2005 Zvejnieku Family Scholarship from Foundation “Vitols Fund”

List of Publications

31. Indole Synthesis by Cobalt-Catalyzed Intramolecular Amidation via the Oxidatively Induced Reductive Elimination Pathway

Cizikovs, A.; Basens, E. E.; Zagorska, P. A., Kinens, A. Grigorjeva, L. ACS Catal., 2024, 14, 1690–1698. DOI:10.1021/acscatal.3c05706

30. Diastereoselective C–H Functionalizations

Cizikovs, A.; Basens, E. E.; Zagorska, P. A.; Grigorjeva, L. In Comprehensive Chirality, 2nd edition (Ed. J. R. Cossy). 2023, Accepted for publication Elsevier Inc. DOI:10.1016/B978-0-32-390644-9.00101-3

29. Phenylglycinol Derived Chemistry

Lidumniece, E.; Bolsakova, J.; Grigorjeva, L. In Comprehensive Chirality, 2nd edition (Ed. J. R. Cossy). 2023, Accepted for publication Elsevier Inc. DOI:10.1016/B978-0-32-390644-9.00100-1

28. Co(III) Intermediates in Cobalt-Catalyzed, Bidentate Chelation Assisted C(sp2)-H Functionalizations

Cizikovs, A.; Grigorjeva, L. Inorganics, 2023, 11(5), 194. DOI:10.3390/inorganics11050194

27. Mechanistic Studies on Cobalt-Catalyzed, Bidentate Chelation-Assisted C-H Bond Functionalization

Lukasevics, L.; Grigorjeva, L. In Handbook of C–H Functionalization, Maiti, D. Ed., Wiley, (2022), In Press. DOI:10.1002/9783527834242.chf0236

26. Cobalt-catalyzed C(sp2)–H bond imination of phenylalanine derivatives

Lukasevics, L.; Cizikovs, A.; Grigorjeva, L. Chem. Commun., 2022, 58, 9754-9757. DOI:10.1039/D2CC02334B

25. C–H bond functionalization by high-valent cobalt catalysis: current progress, challenges and future perspectives

Lukasevics, L.; Cizikovs, A.; Grigorjeva, L. Chem. Commun., 2021, 57, 10827-10841. DOI:10.1039/D1CC04382J



24. Cobalt-Catalyzed C–H Bond Functionalization Using Traceless Directing Group

Cizikovs, A.; Lukasevics, L.; Grigorjeva, L. Tetrahedron 2021, 93, 132307. DOI:10.1016/j.tet.2021.132307



23. Cobalt-Catalyzed Picolinamide-Directed Synthesis of Heterocycles

Lukasevics, L.; Grigorjeva, L. Targets Heterocycl. Syst. (book series) 2021, 25, 144-161. DOI:10.17374/targets.2022.25.144



22. Cobalt-Catalyzed C(sp2)–H Carbonylation of Amino Acids Using Picolinamide as a Traceless Directing Group

Lukasevics, L.; Cizikovs, A.; Grigorjeva, L. Org. Lett., 2021, 23, 2748–2753. DOI:10.1021/acs.orglett.1c00660




21. Synthesis of 1,2-Dihydroisoquinoline-1-Carboxylates Under Cobalt Catalysis

Zagorska, P. A.; Grigorjeva, L.; Bolsakova, J. Chem. Heterocycl. Comp., 2021, 57(2), 159-165. DOI:10.1007/s10593-021-02888-5




20. Cobalt-Catalyzed Carbonylation of The C–H Bond

Lukasvics, L.; Grigorjeva, L., Org. Biomol. Chem., 2020, 18, 7460-7466. DOI:10.1039/D0OB01633K

Graphical abstract: Johnson–Corey–Chaykovsky fluorocyclopropanation of double activated alkenes: scope and limitations



19. Synthesis of 3-Hydroxymethyl Isoindolinones via Cobalt-Catalyzed C(sp2)–H Carbonylation of Phenylglycinol Derivatives

Lukasevics, L.; Cizikovs, A.; Grigorjeva, L., Org. Lett. 2020, 22, 2720-2723. DOI:10.1021/acs.orglett.0c00672



18. Cobalt-Catalyzed, Directed C–H Functionalization/Annulation of Phenylglycinol Derivatives with Alkynes

Bolsakova, J.; Lukasevics, L.; Grigorjeva, L., J. Org. Chem. 2020, 85, 4482-4499. DOI:10.1021/acs.joc.0c00207




17. Cobalt‐Catalyzed Coupling of Benzoic Acid C−H Bonds with Alkynes, Styrenes, and 1,3‐Dienes

Nguyen, T.T.; Grigorjeva, L.; Daugulis, O. Angew. Chem., Int. Ed., 2018, 57, 1688-1691. DOI:10.1002/anie.201711968



16. 1-Amino-1-hydroxymethylcyclobutane Derivatives via Intramolecular Amination of Nonclassical Cyclopropylmethyl Cation

Skvorcova, M.; Grigorjeva, L.; Jirgensons, A. Chem. Heterocycl. Compd., 2017, 53(9), 989-996. DOI:10.1007/s10593-017-2162-1



15. Aminoquinoline-Directed, Cobalt-Catalyzed Carbonylation of Sulfonamide sp2 C–H Bonds

Nguyen, T.T.; Grigorjeva, L.; Daugulis, O. Chem. Commun., 2017, 53, 5136-5138. DOI:10.1039/C7CC02062G



14. Cobalt-Catalyzed, Aminoquinoline-Directed Functionalization of Phosphinic Amide sp2 C–H Bonds

Nguyen, T.T.; Grigorjeva, L.; Daugulis, O. ACS Catal., 2016, 6, 551-554. DOI:10.1021/acscatal.5b02391




13. Synthesis of Alkynyl‐Glycinols by Lewis Acid Catalyzed Propargylic Substitution of Bis‐Imidates

Sirotkina, J.; Grigorjeva, L.; Jirgensons, A. Eur. J. Org. Chem. 2015, 6900-6908. DOI: 10.1002/ejoc.201500937



12. Tetrahydro-1,3-oxazepines via Intramolecular Amination of Cyclopropylmethyl Cation

Skvorcova, M.; Grigorjeva, L.; Jirgensons, A. Org. Lett., 2015, 17, 2902–2904. DOI:10.1021/acs.orglett.5b01014




11. Cobalt-Promoted Dimerization of Aminoquinoline Benzamides

Grigorjeva, L.; Daugulis, O. Org. Lett., 2015, 17, 1204-1207. DOI:10.1021/acs.orglett.5b00155




10. Unsaturated syn– and anti-1,2-Amino Alcohols by Cyclization of Allylic Bis-trichloroacetimidates. Stereoselectivity Dependence on Substrate Configuration

Grigorjeva, L.;  Kinens, A.; Jirgensons, A. J. Org. Chem., 2015, 80, 920–927. DOI:10.1021/jo502404y




9. Cobalt-Catalyzed Direct Carbonylation of Aminoquinoline Benzamides

Grigorjeva, L.; Daugulis, O. Org. Lett., 2014, 16, 4688-4690. DOI:10.1021/ol502007t




8. Cobalt-Catalyzed, Aminoquinoline-Directed Coupling of sp2 C–H Bonds with Alkenes

Grigorjeva, L.; Daugulis, O. Org. Lett., 2014, 16, 4684-4687. DOI:10.1021/ol502005g




7. Cobalt‐Catalyzed, Aminoquinoline‐Directed C(sp2)-H Bond Alkenylation by Alkynes

Grigorjeva, L.; Daugulis, O. Angew. Chem., Int. Ed., 2014, 53, 10209-10212. DOI:10.1002/anie.201404579



6. Semisynthesis of Libiguin A and Its Analogues by Trans-Lactonization of Phragmalin

Grigorjeva, L.; Liepinsh, E.; Razafimahefa, S.; Yahorau, A.; Yahorava, S.; Rasoanaivo, P.; Jirgensons, A.; Wikberg, J.E.S. J. Org. Chem., 2014, 79(9), 4148–4153. DOI:10.1021/jo500318w



5. Unsaturated Amino Alcohols via Cyclization of Allylic Bistrichloroacetimidates

Jirgensons, A.; Grigorjeva, L.; Maleckis, A.; Klimovica, K. Synlett, 2013, 24(18), 2345-2349. DOI:10.1055/s-0033-1338977



4. Synthesis of Cyclic N-Tosyliminocarbonates by Lewis Acid Catalysed Allylic Substitution of Trichloroacetimidates

Grigorjeva, L.; Jirgensons, A. Eur. J. Org. Chem., 2012, 27, 5307–5316. DOI:10.1002/ejoc.201200378



3. Novel Synthesis of 2-Trichloromethyl-4-vinyl-oxazoline and Its Derivatization by Ring Cleavage Reactions

Grigorjeva, L.; Maleckis, A.; Klimovica, K.; Skvorcova, M.; Ivdra, N.; Leitis, G.; Jirgensons, A. Chem. Heterocycl. Compd., 2012, 48, 919-924. Dedicated to professor Ivars Kalvinsh on the occasion of his 65th birthday. DOI:10.1007/s10593-012-1077-0



2. C-Quaternary Vinylglycinols by Metal Catalysed Cyclization of Allylic Bistrichloroacetimidates

Klimovica, K.; Grigorjeva, L.; Maleckis, A.; Popelis, J.; Jirgensons, A. Synlett, 2011, 2849-2851. DOI:10.1055/s-0031-1289537



1. Lewis Acid Catalyzed Intramolecular Allylic Substitution of Bis(trichloroacetimidates): A Versatile Approach to Racemic Unsaturated Amino Acids

Grigorjeva, L.; Jirgensons, A. Eur. J. Org. Chem., 2011, 2421–2425. DOI:10.1002/ejoc.201100060