January 10, 2019

Dr. Liene Grigorjeva

Principal Researcher, Project Leader

E-mail: liene_grigorjeva@osi.lv

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Curriculum Vitae

Carrier Latvian Institute of Organic Synthesis, Riga, Latvia
Since 2018 Principal Researcher
2016 Researcher
2009 Research Assistant
2006 Laboratory Assistant

University of Houston, Houston, USA
2013-2016 Postdoctoral Researcher
Education 2013-2016 Postdoc, University of Houston, USA (Prof. O. Daugulis Group)
2013 Dr. Chem., Faculty of Materials Science and Applied Chemistry, Riga Technical University
2009 M.Sc.Ing. Chem., Faculty of Materials Science and Applied Chemistry,  Riga Technical University  
2007 B.Sc. Chem., Faculty of Materials Science and Applied Chemistry,  Riga Technical University
Awards2016 Chemistry Science Doctoral Award Named After Solomon Hiller
2014 Latvian Institute of Organic Synthesis, E. Lukevics Award for the PhD Thesis
2013 ESF Scholarship for PhD students
2011  LLC “Bapeks” Poster Award in 7th Paul Walden Symposium on Organic Chemistry
2010  Latvian Academy of Science, Martins Straumanis–Alfreds Ievins Award for the Master Thesis
2004–2005 Zvejnieku Family Scholarship from Foundation “Vitols Fund”

List of Publications

17. Cobalt‐Catalyzed Coupling of Benzoic Acid C−H Bonds with Alkynes, Styrenes, and 1,3‐Dienes

Nguyen, T.T.; Grigorjeva, L.; Daugulis, O. Angew. Chem., Int. Ed., 2018, 57, 1688-1691. DOI:10.1002/anie.201711968



16. 1-Amino-1-hydroxymethylcyclobutane Derivatives via Intramolecular Amination of Nonclassical Cyclopropylmethyl Cation

Skvorcova, M.; Grigorjeva, L.; Jirgensons, A. Chem. Heterocycl. Compd., 2017, 53(9), 989-996. DOI:10.1007/s10593-017-2162-1



15. Aminoquinoline-Directed, Cobalt-Catalyzed Carbonylation of Sulfonamide sp2 C–H Bonds

Nguyen, T.T.; Grigorjeva, L.; Daugulis, O. Chem. Commun., 2017, 53, 5136-5138. DOI:10.1039/C7CC02062G



14. Cobalt-Catalyzed, Aminoquinoline-Directed Functionalization of Phosphinic Amide sp2 C–H Bonds

Nguyen, T.T.; Grigorjeva, L.; Daugulis, O. ACS Catal., 2016, 6, 551-554. DOI:10.1021/acscatal.5b02391




13. Synthesis of Alkynyl‐Glycinols by Lewis Acid Catalyzed Propargylic Substitution of Bis‐Imidates

Sirotkina, J.; Grigorjeva, L.; Jirgensons, A. Eur. J. Org. Chem. 2015, 6900-6908. DOI: 10.1002/ejoc.201500937



12. Tetrahydro-1,3-oxazepines via Intramolecular Amination of Cyclopropylmethyl Cation

Skvorcova, M.; Grigorjeva, L.; Jirgensons, A. Org. Lett., 2015, 17, 2902–2904. DOI:10.1021/acs.orglett.5b01014




11. Cobalt-Promoted Dimerization of Aminoquinoline Benzamides

Grigorjeva, L.; Daugulis, O. Org. Lett., 2015, 17, 1204-1207. DOI:10.1021/acs.orglett.5b00155




10. Unsaturated syn– and anti-1,2-Amino Alcohols by Cyclization of Allylic Bis-trichloroacetimidates. Stereoselectivity Dependence on Substrate Configuration

Grigorjeva, L.;  Kinens, A.; Jirgensons, A. J. Org. Chem., 2015, 80, 920–927. DOI:10.1021/jo502404y




9. Cobalt-Catalyzed Direct Carbonylation of Aminoquinoline Benzamides

Grigorjeva, L.; Daugulis, O. Org. Lett., 2014, 16, 4688-4690. DOI:10.1021/ol502007t




8. Cobalt-Catalyzed, Aminoquinoline-Directed Coupling of sp2 C–H Bonds with Alkenes

Grigorjeva, L.; Daugulis, O. Org. Lett., 2014, 16, 4684-4687. DOI:10.1021/ol502005g




7. Cobalt‐Catalyzed, Aminoquinoline‐Directed C(sp2)-H Bond Alkenylation by Alkynes

Grigorjeva, L.; Daugulis, O. Angew. Chem., Int. Ed., 2014, 53, 10209-10212. DOI:10.1002/anie.201404579



6. Semisynthesis of Libiguin A and Its Analogues by Trans-Lactonization of Phragmalin

Grigorjeva, L.; Liepinsh, E.; Razafimahefa, S.; Yahorau, A.; Yahorava, S.; Rasoanaivo, P.; Jirgensons, A.; Wikberg, J.E.S. J. Org. Chem., 2014, 79(9), 4148–4153. DOI:10.1021/jo500318w



5. Unsaturated Amino Alcohols via Cyclization of Allylic Bistrichloroacetimidates

Jirgensons, A.; Grigorjeva, L.; Maleckis, A.; Klimovica, K. Synlett, 2013, 24(18), 2345-2349. DOI:10.1055/s-0033-1338977



4. Synthesis of Cyclic N-Tosyliminocarbonates by Lewis Acid Catalysed Allylic Substitution of Trichloroacetimidates

Grigorjeva, L.; Jirgensons, A. Eur. J. Org. Chem., 2012, 27, 5307–5316. DOI:10.1002/ejoc.201200378



3. Novel Synthesis of 2-Trichloromethyl-4-vinyl-oxazoline and Its Derivatization by Ring Cleavage Reactions

Grigorjeva, L.; Maleckis, A.; Klimovica, K.; Skvorcova, M.; Ivdra, N.; Leitis, G.; Jirgensons, A. Chem. Heterocycl. Compd., 2012, 48, 919-924. Dedicated to professor Ivars Kalvinsh on the occasion of his 65th birthday. DOI:10.1007/s10593-012-1077-0



2. C-Quaternary Vinylglycinols by Metal Catalysed Cyclization of Allylic Bistrichloroacetimidates

Klimovica, K.; Grigorjeva, L.; Maleckis, A.; Popelis, J.; Jirgensons, A. Synlett, 2011, 2849-2851. DOI:10.1055/s-0031-1289537



1. Lewis Acid Catalyzed Intramolecular Allylic Substitution of Bis(trichloroacetimidates): A Versatile Approach to Racemic Unsaturated Amino Acids

Grigorjeva, L.; Jirgensons, A. Eur. J. Org. Chem., 2011, 2421–2425. DOI:10.1002/ejoc.201100060